Evidence-Based Complementary and Alternative Medicine

Research Article

Nearest Neighbor Algorithm Coupled with Metabonomics to Study the Therapeutic Mechanism of Sendeng-4 in Adjuvant-Induced Rheumatoid Arthritis Rat

Potential biomarkers related to RA in rats between CG and MG.


No.	RT (min)	Measured mass	Error (ppm)	Molecular formula	Identified	VIP	ESI mode

(1)	3.47	933.0125	4.6	C₂₀H₂₉N₁₀O₂₃P₅	Guanosine pentaphosphate adenosine	1.4	+
(2)	4.87	606.3497	4.3	C₂₆H₄₃N₁₁O₆	Dynorphin B (6-9)	1.7	+
(3)	4.69	761.3036	1.1	C₃₉H₄₄N₄O₁₂	Bilirubin glucuronide	1.3	+
(4)	1.97	566.4172	1.4	C₂₉H₆₀NO₇P	LysoPE (0:0/24:0)	1.1	+
(5)	2.18	442.0211	9.0	C₁₀H₁₅N₅O₁₁P₂	Guanosine diphosphate	1.5	−
(6)	5.27	283.2648	1.8	C₁₈H₃₆O₂	Stearic acid	2.3	−
(7)	4.82	423.3265	0.9	C₂₉H₄₄O₂	alpha-Tocotrienol	3.5	−
(8)	4.41	327.2318	3.7	C₂₂H₃₂O₂	Docosahexaenoic acid	4.6	−
(9)	4.48	373.2375	2.4	C₂₃H₃₄O₄	Calcitroic acid	1.0	−
(10)	4.28	482.9574	8.1	C₉H₁₅N₂O₁₅P₃	Uridine triphosphate	1.4	−
(11)	4.69	301.2370	4.7	C₁₇H₃₄O₄	MG (0:0/14:0/0:0)	1.0	−
(12)	5.39	309.2804	1.6	C₂₀H₃₈O₂	Eicosenoic acid	1.2	−