Table 1: The essential information of trials included in the meta-analysis.

No.TrialsComparisonsSample sizeProtocolDurationOutcomes

1KUANG Heng (2014) [10]BBR/MET23/28BBR:300mg tid/3 monthsBMI, WHR, FSH, LH, LH/FSH, T, HOMA-IR, TC, TG, HDL-C, LDL-C
MET:500mg bid

2AN Yuan et al. (2014) (2016)[11, 12]BBR/MET/P44/41/43BBR: 500mg tid/3 monthsBMI, WHR, FSH, LH, T, HOMA-IR, FBG, FIN, TC, TG, HDL-C, LDL-C
MET: 500mg tid/
P: 1 tablet tid

3LI Xiaobin e-t al. (2017) [13]BBR/MET26/29BBR:300mg tid/3 monthsBMI, HOMA-IR, FSH, LH, LH/FSH, T, FPG, FIN, TC, TG, HDL-C, LDL-C
MET:500mg bid

4WANG Ling-xiao et al. (2011) [14]MET+BBR/MET28/28MET:500mg tid +BBR:500mg tid /MET:500mg tid3 monthsBMI, LH, FSH, LH/FSH, T, FBS, FIN, HOMA-IR

5WANG Ping et al(2016) [15]MET+BBR/MET42/42MET:500mg tid +BBR:500mg tid /MET:500mg tid3 monthsBMI, WHR, FSH, LH, LH/FSH, HOMA-IR, T,

6MA Yukun e-t al. (2011) [4]CPA+BBR/CPA/CPA+BBR
+MET/ CPA+MET
31/28/33/30CPA:1 tablet qd+BBR:500mg bid/
CPA:1 tablet qd /
3 monthsBMI, WHR, FPG, FIN, HOMA-IR, TC, TG, HDL-C, LDL-C, FSH, T, LH
CPA:1 tablet qd +BBR:500mg bid+MET:500mg tid
CPA:1 tablet qd +MET:500mg tid

7WEI Wei et al.(2012) [16]CPA+BBR/ CPA+MET/CPA +P31/30/28CPA 1 tablet qd+BBR:500mg tid /3 monthsBMI, WHR, FPG, FIN, HOMA-IR, TC, TG, HDL-C, LDL-C
CPA 1 tablet qd +MET:500mg tid /
CPA 1 tablet qd + P:1 tablet bid

8ZHU Qiuyan et al. (2016) [17]CPA+BBR/25/25CPA 1 tablet qd +BBR:300mg tid /
CPA 1 tablet qd + P: 1 tablet tid
3 monthsBMI, WHR, FPG, HOMA-IR, TC, TG FSH, LH, T
CPA +P

9CHEN Xiao et al.(2016) [18]CPA+BBR/50/50CPA 1 tablet qd +BBR:500mg bid /
CPA 1 tablet qd
3 monthsTC, TG, HDL-C, LDL-C, FPG, FIN
CPA

Notes: BBR: berberine; MET: metformin; CPA: cyproterone acetate; P: placebo; qd: once a day; bid: twice a day; tid: three times a day.
BMI: body mass index; FSH: follicle-stimulating hormone; LH: luteinizing hormone; T: testosterone; HOMA-IR: homeostasis model assessment of insulin resistance; TC: total cholesterol; TG: triacylglycerol; DLD-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; WHR: waist hip rate; FIN: fasting insulin; FPG: fasting blood glucose.