Evidence-Based Complementary and Alternative Medicine / 2018 / Article / Fig 9

Research Article

Electroacupuncture Alleviates Pain Responses and Inflammation in a Rat Model of Acute Gout Arthritis

Figure 9

Effect of local administration of specific μ- and κ-opioid receptor agonists on mechanical hyperalgesia of MSU-induced acute gout arthritis rats. Opioid receptor agonists were locally administered to the ankle 7.5 h after MSU injection. PWTs were evaluated 30 min after opioid receptor application. (a-b) Effects of μ-receptor agonist DAMGO (4.9 μg/ankle, panel (a)) and κ-receptor agonist (±) U50488 (1 μg/ankle, panel (b)) injected (i.a.) into the ankle either ipsi (IL) or contralaterally (CL) on the mechanical hyperalgesia of MSU-induced acute gout arthritis rats. versus before MSU injection; versus Model + Veh group. rats/group.

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