Efficacy and Safety of the Injection of the Traditional Chinese Medicine Puerarin for the Treatment of Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis of 53 Randomized Controlled Trials
Table 2
Subgroup analysis.
Subgroups
Trials
Effects models
Pooled effect
95% Cl
value
The total effective rate
Pue + Mec versus Mec
11
Fixed
RR 1.31
1.22–1.41
0.00001
Pue + Vit B1, B12 versus Vit B1, B12
3
Fixed
RR 1.61
1.24–2.10
0.0004
Pue + Epa versus Epa
2
Fixed
RR 1.38
1.12–1.69
0.002
Pue versus Danshen
5
Fixed
RR 1.44
1.24–1.68
0.00001
SNCV of median nerve
Pue + Mec versus Mec
7
Random
MD 3.64
2.78–4.5
0.0001
Pue + Vit B1, B12 versus Vit B1, B12
2
Random
MD 5.43
4.16–6.7
0.00001
Pue + Epa versus Epa
3
Random
MD 3.43
1.28–5.58
0.002
SNCV of peroneal nerve
Pue + Mec versus Mec
8
Random
MD 4.26
2.98–5.55
0.00001
Pue + Vit B1, B12 versus Vit B1, B12
3
Random
MD 3.96
2.94–4.97
0.00001
Pue + Epa versus Epa
3
Random
MD 2.57
0.08–5.06
0.04
Pue versus Danshen
2
Random
MD 3.10
1.91–4.29
0.00001
MNCV of median nerve
Pue + Mec versus Mec
7
Random
MD 5.18
3.51–6.85
0.00001
Pue + Vit B1, B12 versus Vit B1, B12
3
Random
MD 5.14
2.31–7.97
0.0004
Pue + Epa versus Epa
3
Random
MD 2.32
−0.7–5.34
0.13
MNCV of peroneal nerve
Pue + Mec versus Mec
10
Random
MD 4.54
3.23–5.85
0.00001
Pue + Vit B1, B12 versus Vit B1, B12
3
Random
MD 5.01
4.06–5.95
0.00001
Pue + Epa versus Epa
3
Random
MD 2.80
−0.40–6.00
0.09
Pue versus Danshen
2
Random
MD 9.35
−2.13–20.82
0.11
Note. Pue: puerarin; Epa: epalrestat; Mec: mecobalamin; Vit B1, B12: vitamins B1 and B12; Danshen: danshen injection; MD: weighted mean difference; RR: relative risk.
