Fuzi and Banxia Combination, Eighteen Antagonisms in Chinese Medicine, Aggravates Adriamycin-Induced Cardiomyopathy Associated with PKA/β2AR-Gs Signaling

Figure 5

Effect of FB on PKA/β2AR-Gs/Gi signaling. The changes of β2-adrenergic receptor signaling including β2-AR, β2-AR phosphorylation statuses pSer346 and pSer(355,356), protein kinase A (PKA), and G protein-coupled receptor kinase2 (GRK2) were all revealed by western blot. <0.05, <0.01, compared to the control group; <0.01, compared to the ADR group; <0.01, compared to the FL group; <0.05, compared to the BX group; <0.01, compared to the FH group.

(a)

(b)

(c)

(d)

(e)

(f)