Antimycobacterial Activity and Safety Profile Assessment of Alpinia galanga and Tinospora cordifolia
Table 5
Effect of the extracts on biochemical parameters of mice in chronic toxicity test.
Parameters
Extracts
Control
AGDC
%
AGET
%
TCDC
%
TCET
%
166 mg/kg
change
193 mg/kg
change
189 mg/kg
change
170 mg/kg
change
AST(U/l)
102.75 ± 5.21
128.25 ± 6.10
26↑
134.0 ± 4.14
31↑
98.45 ± 5.18
4↓
131.0 ± 5.36
28↑
ALT(U/l)
30.62 ± 2.14
47.97 ± 1.42
56↑
53.92 ± 4.45
76↑
26.7 ± 1.64
13↓
39.62 ± 2.93
35↑
GGT(U/l)
4.75 ± 0.15
6.72 ± 0.23
42↑
5.75 ± 0.29
21↑
3.12 ± 0.08
34↓
4.6 ± 0.28
3↓
ALP(U/l)
320.75 ± 9.64
414.0 ± 8.39
29↑
425.0 ± 6.64
32↑
347.50 ± 7.55
8↑
385.5 ± 6.06
12↑
Bilirubin(mg/dl)
0.52 ± 0.01
0.77 ± 0.01
47↑
0.71 ± 0.02
36↑
0.50 ± 0.01
0.68 ± 0.02
30↑
Glucose(mg/dl)
122.0 ± 4.88
196.25 ± 7.18
61↑
136.25 ± 6.26
11↑
77.90 ± 0.02
36↓
123.50 ± 8.45
Sodium (mEq/L)
84.18 ± 1.97
107.14 ± 2.8
27↑
99.10 ± 2.36
17↑
117.47 ± 3.9
40↑
105.99 ± 1.9
26↑
Potassium (mEq/L)
5.0 ± 0.02
7.22 ± 0.28
45↑
6.97 ± 0.11
40↑
6.6 ± 0.12
32↑
5.60 ± 0.12
12↑
Calcium (mg/dl)
7.42 ± 0.59
5.61 ± 0.66
24↓
5.52 ± 0.65
26
5.23 ± 0.42
29↓
6.95 ± 0.47
6↓
Urea (nmol/l)
39.1 ± 1.78
38.95 ± 1.41
29.92 ± 3.50
23↓
59.35 ± 4.26
52↑
65.0 ± 3.53
66↑
Uric acid (mg/dl)
6.97 ± 0.25
4.95 ± 0.09
29↓
8.87 ± 0.30
27↑
6.87 ± 0.30
10.27 ± 0.45
47↑
Creatinine (mg/dl)
0.92 ± 0.04
1.01 ± 0.04
9↑
1.27 ± 0.02
38↑
1.44 ± 0.02
56↑
1.52 ± 0.09
65↑
All values represent mean ± SEM. p < 0.05; p < 0.01; p < 0.001; ANOVA, followed by Dunnett’s multiple comparison test. Test value compared with control group
