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Evidence-Based Complementary and Alternative Medicine
Volume 2018, Article ID 3039783, 10 pages
https://doi.org/10.1155/2018/3039783
Research Article

Electroacupuncture Reduces Weight in Diet-Induced Obese Rats via Hypothalamic Tsc1 Promoter Demethylation and Inhibition of the Activity of mTORC1 Signaling Pathway

1Chengdu University of Traditional Chinese Medicine, Chengdu, China
2Department of Acupuncture, Hospital of Traditional Chinese Medicine, Dazu District, Chongqing, China
3Department of Cardiology, The Third People’s Hospital of Chengdu, Chengdu, China
4The Third Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Diabetes Mellitus Prevention and Control Center of Sichuan Province, Chengdu, China

Correspondence should be addressed to Lin Zhang; nc.ude.mctudc@xhlgnahz and Ying Li; nc.ude.mctudc@gniyil

Received 2 December 2017; Revised 9 March 2018; Accepted 1 April 2018; Published 26 April 2018

Academic Editor: Mariangela Rondanelli

Copyright © 2018 Jincheng Leng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. A. Grover, M. Kaouache, P. Rempel et al., “Years of life lost and healthy life-years lost from diabetes and cardiovascular disease in overweight and obese people: A modelling study,” The Lancet Diabetes & Endocrinology, vol. 3, no. 2, pp. 114–123, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Kyrgiou, I. Kalliala, G. Markozannes et al., “Adiposity and cancer at major anatomical sites: Umbrella review of the literature,” BMJ, vol. 356, article no. j477, 2017. View at Publisher · View at Google Scholar · View at Scopus
  3. World Health Organization, 10 Facts on Obesity, 2017, http://wwwwhoint/features/factfiles/obesity/en/.
  4. Collaboration NCDRF, “Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants,” Lancet, vol. 387, no. 10026, pp. 1377–1396, 2016. View at Publisher · View at Google Scholar
  5. S. J. Van Dijk, P. L. Molloy, H. Varinli et al., “Epigenetics and human obesity,” International Journal of Obesity, vol. 39, no. 1, pp. 85–97, 2015. View at Publisher · View at Google Scholar · View at Scopus
  6. D. Pestana, D. Teixeira, M. Meireles et al., “Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p'-DDE,” Scientific Reports, vol. 7, no. 1, article no. 2738, 2017. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Weiner, K. Rohde, K. Krause et al., “Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylation,” Molecular Metabolism, vol. 6, no. 6, pp. 482–493, 2017. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Aronica, A. J. Levine, K. Brennan et al., “A systematic review of studies of DNA methylation in the context of a weight loss intervention,” Epigenomics, vol. 9, no. 5, pp. 769–787, 2017. View at Publisher · View at Google Scholar · View at Scopus
  9. L. Zhang, K. Li, H. He, and M.-Q. Hu, “Tsc1 promoter methylation rate, mTOR expression in food-induced obese rat hypothalamus,” Journal of Sichuan University (Medical Science Edition), vol. 46, no. 1, pp. 47–50, 2015. View at Google Scholar · View at Scopus
  10. E. Silva, F. J. Rosario, T. L. Powell, and T. Jansson, “Mechanistic target of rapamycin is a novel molecular mechanism linking folate availability and cell function,” Journal of Nutrition, vol. 147, no. 7, pp. 1237–1242, 2017. View at Publisher · View at Google Scholar · View at Scopus
  11. R. A. Saxton and D. M. Sabatini, “mTOR in Growth, Metabolism, and Disease,” Cell, vol. 168, no. 6, pp. 960–976, 2017. View at Publisher · View at Google Scholar
  12. F. Hu, Y. Xu, and F. Liu, “Hypothalamic roles of mTOR complex I: Integration of nutrient and hormone signals to regulate energy homeostasis,” American Journal of Physiology-Endocrinology and Metabolism, vol. 310, no. 11, pp. E994–E1002, 2016. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Takei, K. Furukawa, O. Hanyu, H. Sone, and H. Nawa, “A possible link between BDNF and mTOR in control of food intake,” Frontiers in Psychology, vol. 5, article no. 1093, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Esteghamati, T. Mazaheri, M. V. Rad, and S. Noshad, “Complementary and alternative medicine for the treatment of obesity: A critical review,” International Journal of Endocrinology and Metabolism, vol. 13, no. 2, Article ID e19678, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Belivani, C. Dimitroula, N. Katsiki, M. Apostolopoulou, M. Cummings, and A. I. Hatzitolios, “Acupuncture in the treatment of obesity: a narrative review of the literature,” Acupuncture in Medicine, vol. 31, no. 1, pp. 88–97, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Sui, H. L. Zhao, V. C. W. Wong et al., “A systematic review on use of chinese medicine and acupuncture for treatment of obesity,” Obesity Reviews, vol. 13, no. 5, pp. 409–430, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Deng, Y. Long, Y.-R. Yu, and M.-R. Li, “Adiponectin directly improves endothelial dysfunction in obese rats through the AMPK-eNOS Pathway,” International Journal of Obesity, vol. 34, no. 1, pp. 165–171, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. P. C. Chandler, J. B. Viana, K. D. Oswald, P. K. Wauford, and M. M. Boggiano, “Feeding response to melanocortin agonist predicts preference for and obesity from a high-fat diet,” Physiology & Behavior, vol. 85, no. 2, pp. 221–230, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Wang, W.-J. Liu, G.-M. Shen, M.-T. Zhang, S. Huang, and Y. He, “Neural mechanism of gastric motility regulation by electroacupuncture at RN12 and BL21: A paraventricular hypothalamic nucleus-dorsal vagal complex-vagus nervegastric channel pathway,” World Journal of Gastroenterology, vol. 21, no. 48, pp. 13480–13489, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Tabosa, Y. Yamamura, E. R. Forno, and L. E. A. M. Mello, “Effect of the acupoints ST-36 (Zusanli) and SP-6 (Sanyinjiao) on intestinal myoelectric activity of Wistar rats,” Brazilian Journal of Medical and Biological Research, vol. 35, no. 6, pp. 731–739, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Xu, L. Chen, L. Tang et al., “Electroacupuncture inhibits weight gain in diet-induced obese rats by activating hypothalamicLKB1-AMPK signaling,” BMC Complementary and Alternative Medicine, vol. 15, no. 1, article no. 147, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Mori, K. Inoki, H. Münzberg et al., “Critical Role for Hypothalamic mTOR Activity in Energy Balance,” Cell Metabolism, vol. 9, no. 4, pp. 362–374, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. D. Cota, K. Proulx, K. A. Blake Smith et al., “Hypothalamic mTOR signaling regulates food intake,” Science, vol. 312, no. 5775, pp. 927–930, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Cota, E. K. Matter, S. C. Woods, and R. J. Seeley, “The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity,” The Journal of Neuroscience, vol. 28, no. 28, pp. 7202–7208, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Inoki, M. N. Corradetti, and K. L. Guan, “Dysregulation of the TSC-mTOR pathway in human disease,” Nature Genetics, vol. 37, no. 1, pp. 19–24, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Haig, “The (dual) origin of epigenetics,” Cold Spring Harbor Symposium on Quantitative Biology, vol. 69, pp. 67–70, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Kokosar, A. Benrick, A. Perfilyev et al., “A single bout of electroacupuncture remodels epigenetic and transcriptional changes in adipose tissue in polycystic ovary syndrome,” Scientific Reports, vol. 8, no. 1, 2018. View at Publisher · View at Google Scholar
  28. C.-K. Wen and T.-Y. Lee, “Electroacupuncture prevents white adipose tissue inflammation through modulation of hypoxia-inducible factors-1aα-dependent pathway in obese mice,” BMC Complementary and Alternative Medicine, vol. 15, no. 1, article no. 452, 2015. View at Publisher · View at Google Scholar · View at Scopus
  29. R. R. Kanherkar, S. E. Stair, N. Bhatia-Dey, P. J. Mills, D. Chopra, and A. B. Csoka, “Epigenetic mechanisms of integrative medicine,” Evidence-Based Complementary and Alternative Medicine, vol. 2017, Article ID 4365429, 2017. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Jaenisch and A. Bird, “Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals,” Nature Genetics, vol. 33, pp. 245–254, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. S. C. Williams, “Epigenetics,” Proceedings of the National Acadamy of Sciences of the United States of America, vol. 110, no. 9, pp. 3209–3209, 2013. View at Publisher · View at Google Scholar
  32. S. E. Ackerman, O. A. Blackburn, F. Marchildon, and P. Cohen, “Insights into the Link Between Obesity and Cancer,” Current Obesity Reports, vol. 6, no. 2, pp. 195–203, 2017. View at Publisher · View at Google Scholar
  33. J. Zheng, M. Zhao, J. Li et al., “Obesity-associated digestive cancers: A review of mechanisms and interventions,” Tumor Biology, vol. 39, no. 3, p. 101042831769502, 2017. View at Publisher · View at Google Scholar
  34. X. Du, K. Hidayat, and B.-M. Shi, “Abdominal obesity and gastroesophageal cancer risk: Systematic review and meta-analysis of prospective studies,” Bioscience Reports, vol. 37, no. 3, Article ID BSR20160474, 2017. View at Publisher · View at Google Scholar · View at Scopus
  35. K. Hidayat, X. Du, G. Chen, M. Shi, and B. Shi, “Abdominal obesity and lung cancer risk: Systematic review and meta-analysis of prospective studies,” Nutrients, vol. 8, no. 12, article no. 810, 2016. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Pérez-Mendoza, D. Luna-Moreno, A. Carmona-Castro et al., “Neotomodon alstoni mice present sex differences between lean and obese in daily hypothalamic leptin signaling,” Chronobiology International, vol. 34, no. 7, pp. 956–966, 2017. View at Publisher · View at Google Scholar · View at Scopus
  37. K. Timper and J. C. Brüning, “Hypothalamic circuits regulating appetite and energy homeostasis: Pathways to obesity,” Disease Models & Mechanisms, vol. 10, no. 6, pp. 679–689, 2017. View at Publisher · View at Google Scholar · View at Scopus
  38. C. Kreutzer, S. Peters, D. M. Schulte et al., “Hypothalamic inflammation in human obesity is mediated by environmental and genetic factors,” Diabetes, vol. 66, no. 9, pp. 2407–2415, 2017. View at Publisher · View at Google Scholar · View at Scopus
  39. A. W. Kinyua, D. J. Yang, I. Chang, and K. W. Kim, “Steroidogenic factor 1 in the ventromedial nucleus of the hypothalamus regulates age-dependent obesity,” PLoS ONE, vol. 11, no. 9, Article ID e0162352, 2016. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Nakata, S. Yamamoto, T. Okada, and T. Yada, “AAV-mediated IL-10 gene transfer counteracts inflammation in the hypothalamic arcuate nucleus and obesity induced by high-fat diet,” Neuropeptides, vol. 62, pp. 87–92, 2017. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Fraser, C. K. Dhaliwal, M. H. Vickers, S. O. Krechowec, and B. H. Breier, “Diet-induced obesity and prenatal undernutrition lead to differential neuroendocrine gene expression in the hypothalamic arcuate nuclei,” Endocrine Journal, vol. 53, no. 3, pp. 839–847, 2016. View at Publisher · View at Google Scholar · View at Scopus
  42. P. Santoso, M. Nakata, K. Shiizaki et al., “Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states,” Scientific Reports, vol. 7, Article ID 45819, 2017. View at Publisher · View at Google Scholar · View at Scopus
  43. Y. Chen, Y.-C. Lin, T.-W. Kuo, and Z. A. Knight, “Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits,” Cell, vol. 160, no. 5, pp. 829–841, 2015. View at Publisher · View at Google Scholar · View at Scopus
  44. C. Cansell, R. G. P. Denis, A. Joly-Amado, J. Castel, and S. Luquet, “Arcuate AgRP neurons and the regulation of energy balance,” Frontiers in Endocrinology, vol. 3, Article ID Article 169, 2012. View at Publisher · View at Google Scholar · View at Scopus
  45. H. T. M. D. Le, A. R. Angotzi, L. O. E. Ebbesson, Ø. Karlsen, and I. Rønnestad, “The ontogeny and brain distribution dynamics of the appetite regulators NPY, CART and pOX in larval Atlantic cod (Gadus morhua L.),” PLoS ONE, vol. 11, no. 4, Article ID e0153743, 2016. View at Publisher · View at Google Scholar · View at Scopus
  46. Y.-S. Hsieh, P.-N. Chen, C.-H. Yu, C.-H. Chen, T.-T. Tsai, and D.-Y. Kuo, “Involvement of oxidative stress in the regulation of NPY/CART-mediated appetite control in amphetamine-treated rats,” NeuroToxicology, vol. 48, pp. 131–141, 2015. View at Publisher · View at Google Scholar · View at Scopus
  47. K. K. Mahawar and A. J. Sharples, “Contribution of Malabsorption to Weight Loss After Roux-en-Y Gastric Bypass: a Systematic Review,” Obesity Surgery, vol. 27, no. 8, pp. 2194–2206, 2017. View at Publisher · View at Google Scholar · View at Scopus
  48. V. Shettar, S. Patel, and S. Kidambi, “Epidemiology of Obesity and Pharmacologic Treatment Options,” Nutrition in Clinical Practice, vol. 32, no. 4, pp. 441–462, 2017. View at Publisher · View at Google Scholar · View at Scopus
  49. F. Wang, D. R. Tian, P. Tso, and J. S. Han, “Arcuate nucleus of hypothalamus is involved in mediating the satiety effect of electroacupuncture in obese rats,” Peptides, vol. 32, no. 12, pp. 2394–2399, 2011. View at Publisher · View at Google Scholar · View at Scopus
  50. D.-R. Tian, X.-D. Li, F. Wang et al., “Up-regulation of the expression of cocaine and amphetamine-regulated transcript peptide by electroacupuncture in the arcuate nucleus of diet-induced obese rats,” Neuroscience Letters, vol. 383, no. 1-2, pp. 17–21, 2005. View at Publisher · View at Google Scholar · View at Scopus
  51. J. S. You and C. C. Hung, “Effect of electroacupuncture on plasma of leptin and insulin in diet-induced obese rats,” Jouranl Chinnese Medical, vol. 16, no. 4, pp. 101–109, 2005. View at Google Scholar
  52. L. Y. Sun, D. Y. Sun, H. L. Xiao et al., “Electroacupuncture on leptin of Both Sexes in the Hypothalamus of obese rats,” Journal of Zhejiang Chinese Medical University, vol. 36, no. 4, pp. 430–432, 2012. View at Google Scholar