Research Article

Antileishmanial and Immunomodulatory Effect of Babassu-Loaded PLGA Microparticles: A Useful Drug Target to Leishmania amazonensis Infection

Table 1

Diameter, zeta potential, efficiency of encapsulation, and polydispersion index of PLGA microparticles loaded with the aqueous extract of babassu mesocarp with or without 6-coumarin.


(μm)
Zeta
(mV)
%EEPDI

CMP5 ± 0.8−23 ± 0.80,401 ± 0,05
CMP6-coumarin5 ± 0.6−17 ± 0.6NA0,676 ± 0,11
MMP6 ± 0.9−26 ± 0.345 ± 50,703 ± 0,20
MMP6-coumarin3 ± 0.2−34 ± 1.842 ± 30,884 ± 0,05

(a) CMP: unloaded microparticles. MMP: microparticles loaded with the aqueous extract of babassu mesocarp. CMP6-coumarin: microparticles loaded with the fluorescent dye 6- coumarin and MMP6-coumarin: microparticles loaded with the aqueous extract of babassu mesocarp and the fluorescent dye 6-coumarin.
(b) Values are the mean ± standard deviation of samples tested in quintuplicate.
(c) EE: entrapment efficiency.
(d) NA: not applicable