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Evidence-Based Complementary and Alternative Medicine
Volume 2018 (2018), Article ID 3479083, 11 pages
https://doi.org/10.1155/2018/3479083
Research Article

Beneficial Effects of Gagam-Palmultang on Scopolamine-Induced Memory Deficits in Mice

1Korean Medical Science Research Center for Healthy-Aging, Pusan National University, Yangsan 50612, Republic of Korea
2Department of Korean Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea
3Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea
4Graduate Training Program of Korean Medicine for Healthy-Aging, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea

Correspondence should be addressed to Byung Tae Choi; rk.ca.nasup@tbiohc

Received 6 November 2017; Revised 28 December 2017; Accepted 14 January 2018; Published 18 February 2018

Academic Editor: Krishnadas Nandakumar

Copyright © 2018 Yu Ri Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. T. Bartus and R. L. Dean III, “Pharmaceutical treatment for cognitive deficits in Alzheimer's disease and other neurodegenerative conditions: Exploring new territory using traditional tools and established maps,” Psychopharmacology, vol. 202, no. 1-3, pp. 15–36, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. O. Lazarov, M. P. Mattson, D. A. Peterson, S. W. Pimplikar, and H. van Praag, “When neurogenesis encounters aging and disease,” Trends in Neurosciences, vol. 33, no. 12, pp. 569–579, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. P. E. Gold, “Acetylcholine modulation of neural systems involved in learning and memory,” Neurobiology of Learning and Memory, vol. 80, no. 3, pp. 194–210, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Mohapel, G. Leanza, M. Kokaia, and O. Lindvall, “Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning,” Neurobiology of Aging, vol. 26, no. 6, pp. 939–946, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Contestabile, “The history of the cholinergic hypothesis,” Behavioural Brain Research, vol. 221, no. 2, pp. 334–340, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. J. K. Blusztajn and R. J. Wurtman, “Choline and cholinergic neurons,” Science, vol. 221, no. 4611, pp. 614–620, 1983. View at Publisher · View at Google Scholar · View at Scopus
  7. E. P. Brandon, T. Mellott, D. P. Pizzo et al., “Choline transporter 1 maintains cholinergic function in choline acetyltransferase haploinsufficiency,” The Journal of Neuroscience, vol. 24, no. 24, pp. 5459–5466, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. D. K. Lahiri, J. T. Rogers, N. H. Greig, and K. Sambamurti, “Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents,” Current Pharmaceutical Design, vol. 10, no. 25, pp. 3111–3119, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Seoane, C. J. Tinsley, and M. W. Brown, “Interfering with perirhinal brain-derived neurotrophic factor expression impairs recognition memory in rats,” Hippocampus, vol. 21, no. 2, pp. 121–126, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. E. Bruel-Jungerman, P. J. Lucassen, and F. Francis, “Cholinergic influences on cortical development and adult neurogenesis,” Behavioural Brain Research, vol. 221, no. 2, pp. 379–388, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. C. K. Callaghan and Á. M. Kelly, “Differential BDNF signaling in dentate gyrus and perirhinal cortex during consolidation of recognition memory in the rat,” Hippocampus, vol. 22, no. 11, pp. 2127–2135, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Bekinschtein, M. Cammarota, C. Katche et al., “BDNF is essential to promote persistence of long-term memory storage,” Proceedings of the National Acadamy of Sciences of the United States of America, vol. 105, no. 7, pp. 2711–2716, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Wu, D. Lu, H. Jiang et al., “Simvastatin-mediated upregulation of VEGF and BDNF, activation of the PI3K/Akt pathway, and increase of neurogenesis are associated with therapeutic improvement after traumatic brain injury,” Journal of Neurotrauma, vol. 25, no. 2, pp. 130–139, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Lin, C. Wang, B. Xu et al., “The VGF-derived peptide TLQP62 produces antidepressant-like effects in mice via the BDNF/TrkB/CREB signaling pathway,” Pharmacology Biochemistry & Behavior, vol. 120, pp. 140–148, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. W. Zhou, X. Cheng, and Y. Zhang, “Effect of Liuwei Dihuang decoction, a traditional Chinese medicinal prescription, on the neuroendocrine immunomodulation network,” Pharmacology & Therapeutics, vol. 162, pp. 170–178, 2016. View at Publisher · View at Google Scholar · View at Scopus
  16. Q. Yuan, C.-W. Wang, J. Shi, and Z.-X. Lin, “Effects of Ginkgo biloba on dementia: An overview of systematic reviews,” Journal of Ethnopharmacology, vol. 195, pp. 1–9, 2017. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Gao and Z. Nan, Korean-Chinese-English Oriental Medicine Dictionary, Seoul, Republic of Korea, 2001.
  18. M. E. Pak, Y. R. Kim, H. N. Kim et al., “Studies on medicinal herbs for cognitive enhancement based on the text mining of Dongeuibogam and preliminary evaluation of its effects,” Journal of Ethnopharmacology, vol. 179, pp. 383–390, 2016. View at Publisher · View at Google Scholar · View at Scopus
  19. Y.-C. Oh, Y. H. Jeong, W.-K. Cho, M.-J. Gu, and J. Y. Ma, “Inhibitory effects of palmultang on inflammatory mediator production related to suppression of NF-κB and MAPK pathways and induction of HO-1 expression in macrophages,” International Journal of Molecular Sciences, vol. 15, no. 5, pp. 8443–8457, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. Y.-J. Yun, B. Lee, D.-H. Hahm et al., “Neuroprotective effect of Palmul-Chongmyeong-Tang on ischemia-induced learning and memory deficits in the rat,” Biological & Pharmaceutical Bulletin, vol. 30, no. 2, pp. 337–342, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. B. Kook, S. C. Kim, S. D. Park, S. K. Park, B. I. Seo, Y. B. Seo et al., Bangjaehak (The Herbal Formula Study), Yeongrimsa, Seoul, Republic of Korea, 2009.
  22. I. Klinkenberg and A. Blokland, “The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies,” Neuroscience & Biobehavioral Reviews, vol. 34, no. 8, pp. 1307–1350, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. C. V. Vorhees and M. T. Williams, “Morris water maze: procedures for assessing spatial and related forms of learning and memory,” Nature Protocols, vol. 1, no. 2, pp. 848–858, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Bromley-Brits, Y. Deng, and W. Song, “Morris water maze test for learning and memory deficits in Alzheimer's disease model mice,” Journal of Visualized Experiments, no. 53, Article ID e2920, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Sakurai, M. Sekiguchi, K. Zushida et al., “Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene,” European Journal of Neuroscience, vol. 27, no. 3, pp. 691–701, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Yamada, Y. Santo-Yamada, and K. Wada, “Stress-induced impairment of inhibitory avoidance learning in female neuromedin B receptor-deficient mice,” Physiology & Behavior, vol. 78, no. 2, pp. 303–309, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Eichenbaum, “How does the brain organize memories?” Science, vol. 277, no. 5324, pp. 330–332, 1997. View at Publisher · View at Google Scholar · View at Scopus
  28. E. Giacobini, “Cholinesterase inhibitors: new roles and therapeutic alternatives,” Pharmacological Research, vol. 50, no. 4, pp. 433–440, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. G. Grön, I. Brandenburg, A. P. Wunderlich, and M. W. Riepe, “Inhibition of hippocampal function in mild cognitive impairment: Targeting the cholinergic hypothesis,” Neurobiology of Aging, vol. 27, no. 1, pp. 78–87, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Moosavi, G. Yadollahi Khales, L. Abbasi, A. Zarifkar, and K. Rastegar, “Agmatine protects against scopolamine-induced water maze performance impairment and hippocampal ERK and Akt inactivation,” Neuropharmacology, vol. 62, no. 5-6, pp. 2018–2023, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Cazorla, J. Prémont, A. Mann, N. Girard, C. Kellendonk, and D. Rognan, “Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice,” The Journal of Clinical Investigation, vol. 121, no. 5, pp. 1846–1857, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. Á. Kelly and M. A. Lynch, “Long-term potentiation in dentate gyrus of the rat is inhibited by the phosphoinositide 3-kinase inhibitor, wortmannin,” Neuropharmacology, vol. 39, no. 4, pp. 643–651, 2000. View at Publisher · View at Google Scholar · View at Scopus
  33. J. M. Horwood, F. Dufour, S. Laroche, and S. Davis, “Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat,” European Journal of Neuroscience, vol. 23, no. 12, pp. 3375–3384, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. M. G. Giovannini, “The role of the extracellular signal-regulated kinase pathway in memory encoding,” Reviews in the Neurosciences, vol. 17, no. 6, pp. 619–634, 2006. View at Google Scholar · View at Scopus
  35. R. S. Bitner, “Cyclic AMP response element-binding protein (CREB) phosphorylation: a mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics,” Biochemical Pharmacology, vol. 83, no. 6, pp. 705–714, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. M.-X. Silveyra, M.-S. García-Ayllón, C. Serra-Basante et al., “Changes in acetylcholinesterase expression are associated with altered presenilin-1 levels,” Neurobiology of Aging, vol. 33, no. 3, pp. 627–e37, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. H. R. Park, H. Lee, H. Park, W.-K. Cho, and J. Y. Ma, “Fermented Sipjeondaebo-tang Alleviates Memory Deficits and Loss of Hippocampal Neurogenesis in Scopolamine-induced Amnesia in Mice,” Scientific Reports, vol. 6, Article ID 22405, 2016. View at Publisher · View at Google Scholar · View at Scopus
  38. S. Kotani, T. Yamauchi, T. Teramoto, and H. Ogura, “Pharmacological evidence of cholinergic involvement in adult hippocampal neurogenesis in rats,” Neuroscience, vol. 142, no. 2, pp. 505–514, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. C.-S. Seo, M.-Y. Lee, H.-S. Lim et al., “Determination of 5-hydroxymethyl-2-furfural, albiflorin, paeoniflorin, liquiritin, ferulic acid, nodakenin, and glycyrrhizin by HPLC-PDA, and evaluation of the cytotoxicity of Palmul-tang, a traditional Korean herbal medicine,” Archives of Pharmacal Research, vol. 35, no. 1, pp. 101–108, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. B. Lee, J. B. Weon, B.-R. Yun, J. Lee, M. R. Eom, and C. J. Ma, “Simultaneous determination of 11 major components in palmul-tang by HPLC-DAD and LC-MS-MS,” Journal of Chromatographic Science (JCS), vol. 52, no. 6, pp. 482–492, 2014. View at Publisher · View at Google Scholar · View at Scopus
  41. A. Liu, X. Zhao, H. Li et al., “5-Hydroxymethylfurfural, an antioxidant agent from Alpinia oxyphylla Miq. improves cognitive impairment in Aβ1–42 mouse model of Alzheimer's disease,” International Immunopharmacology, vol. 23, no. 2, pp. 719–725, 2014. View at Publisher · View at Google Scholar
  42. S.-L. Jia, X.-L. Wu, X.-X. Li et al., “Neuroprotective effects of liquiritin on cognitive deficits induced by soluble amyloid-β1–42oligomers injected into the hippocampus,” Journal of Asian Natural Products Research, vol. 18, no. 12, pp. 1186–1199, 2016. View at Publisher · View at Google Scholar · View at Scopus
  43. F.-S. Tsai, L.-Y. Wu, S.-E. Yang et al., “Ferulic acid reverses the cognitive dysfunction caused by amyloid β peptide 1-40 through anti-oxidant activity and cholinergic activation in rats,” American Journal of Chinese Medicine, vol. 43, no. 2, pp. 319–335, 2015. View at Publisher · View at Google Scholar · View at Scopus
  44. K. Tabata, K. Matsumoto, and H. Watanabe, “Paeoniflorin, a major constituent of peony root, reverses muscarinic M1-receptor antagonist-induced suppression of long-term potentiation in the rat hippocampal slice,” Japanese Journal of Pharmacology, vol. 83, no. 1, pp. 25–30, 2000. View at Publisher · View at Google Scholar · View at Scopus
  45. Q. Gao, S. J. Jeon, H. A. Jung et al., “Nodakenin Enhances Cognitive Function and Adult Hippocampal Neurogenesis in Mice,” Neurochemical Research, vol. 40, no. 7, pp. 1438–1447, 2015. View at Publisher · View at Google Scholar · View at Scopus
  46. J. Zhu, X. Mu, J. Zeng et al., “Ginsenoside rg1 prevents cognitive impairment and hippocampus senescence in a rat model of d-galactose-induced aging,” PLoS ONE, vol. 9, no. 6, Article ID e101291, 2014. View at Publisher · View at Google Scholar
  47. Y.-Q. Shi, T.-W. Huang, L.-M. Chen et al., “Ginsenoside Rg1 attenuates amyloid-β content, regulates PKA/CREB activity, and improves cognitive performance in SAMP8 mice,” Journal of Alzheimer's Disease, vol. 19, no. 3, pp. 977–989, 2010. View at Publisher · View at Google Scholar · View at Scopus
  48. W. Wang, X. Chen, J. Zhang et al., “Glycyrrhizin attenuates isoflurane-induced cognitive deficits in neonatal rats via its anti-inflammatory activity,” Neuroscience, vol. 316, pp. 328–336, 2016. View at Publisher · View at Google Scholar · View at Scopus