Hepatoprotective and Anti-Inflammatory Activities of the Cnidoscolus chayamansa (Mc Vaugh) Leaf Extract in Chronic Models

Table 2

Anti-inflammatory effect of C. chayamansa extract and primary fractions F14-42 on the TPA model.

Treatment 1	Dose; (mg/kg)	T(6h)	Inhibition percentage (%)	ED50; (mg/kg)
TPA	-	20.60±0.64	---	---
	0.5	16.92±0.	17.88%
IND	1	14.07±0.	41.77%	2.14
	2	10.77±0.	47.73%
CnCM	0.5	17.43±0.	15.37%	1.58
	1	11.48±0.	44.26%
	2	9.45±0.	54.13%
Treatment 2
IND	0.5	8.62±0.23	45.64%	1.28
	1	7.9±0.44	50.18%
	2	5.68±0.	64.18%
Primary fraction 14-42	0.5	9.42±0.56	15.37%	1.48; (R^2=0.99)
	1	8.58±0.64	44.26%
	2	7.46±0.	54.13%

Data shown as mean (±), with standard error of the mean (SEM). Statistical analysis two-way ANOVA and post hoc SNK test (p ≤0.05). Treatment 1: TPA control, IND, CnCM 0.5 mg/ear, and CnCM 1 mg/ear. Treatment 2: TPA control, IND 0.5 mg/ear, IND 1 mg/ear, fractions 14-42 0.5 mg/ear, and fractions 14-42 1 mg/ear; CnCM: extract CHCl₃:MeOH; IND: Indomethacin; n = 6.