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Evidence-Based Complementary and Alternative Medicine
Volume 2018, Article ID 3908453, 11 pages
Research Article

Enhancement of Lipid Metabolism and Hepatic Stability in Fat-Induced Obese Mice by Fermented Cucurbita moschata Extract

1College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea
2Veterinary Drugs & Biologics Division, Animal and Plant Quarantine Agency (APQA), 177 Hyeoksin 8-ro, Gimcheon-si, Gyeongsangbuk-do 39660, Republic of Korea
3Department of Food Science and Technology, Keimyung University, Daegu 704-701, Republic of Korea
4The Aramfarm Co., Ltd, Gyeongsan 38497, Republic of Korea

Correspondence should be addressed to Sam-Pin Lee; and Seung-Chun Park;

Received 28 February 2017; Accepted 17 December 2017; Published 13 March 2018

Academic Editor: Srinivas Nammi

Copyright © 2018 Md. Akil Hossain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to evaluate the potentials of fermented Cucurbita moschata extract (FCME) in the treatment of obesity and nonalcoholic fatty liver disease (NAFLD). Five-week-old male C57BL/6 mice were assigned to 6 groups and treated for 8 weeks by feeding the normal diet (ND) and high fat diet (HFD) with and without FCME. Changes in body weight gain and consumption of feed and water were recorded. Major organs, adipose tissues, and blood samples were collected after the experimental period. The serum lipid profile, histological features of liver and adipose tissues, and mRNA expression of different adipogenic/lipogenic genes from liver tissue were evaluated. The supplementation of FCME in HFD significantly prevented HFD-induced increment of bodyweight. The adipose tissue mass, liver enzymes, and plasma lipids were also reduced significantly by the consumption of FCME. The mRNA expressions of adipogenic/lipogenic genes (PPARγ, C/EBPα, C/EBPβ, C/EBPγ, and SREBP-1C) in FCME-treated obese mice were considerably suppressed. FCME showed its antiobesity potential by suppressing the body weight gain and by modulating the plasma lipids and liver enzymes through the regulation of adipogenic/lipogenic transcriptional factors. Fermented Cucurbita moschata could be an opportunistic agent in controlling obesity and fatty liver changes.