Pharmacokinetics and Tissue Distribution Study of Pinosylvin in Rats by Ultra-High-Performance Liquid Chromatography Coupled with Linear Trap Quadrupole Orbitrap Mass Spectrometry

Table 5

Noncompartmental pharmacokinetic parameters of pinosylvin in rats after oral administration (n=6, means ± SD).

Pharmacokinetic parameters	Unit	Value
t1/2	h	1.347±0.01
	h	0.137±0.016
	L/kg	434.716±25.508
CL	L/h/kg	223.635±11.866
	ng/ml	164.231±64.264
	h	3.209±0.129
	h	3.210±0.129
	ng/ml h	711.142±46.885
	ng/ml h	711.195±46.885

T_1/2: elimination half-life; : time to peak concentration; : volume of distribution; CL: clearance; : peak plasma concentration; MRT: mean retention time; AUC: area under the curve.