Protective Effect of Jianpiyifei II Granule against Chronic Obstructive Pulmonary Disease via NF-κB Signaling Pathway

Figure 4

JPYF II decreased mRNA expression of proinflammatory cytokines and MMPs in lung tissues caused by LPS and CS exposure. (a) TNF-α, (b) IL-6, (c) IL-1β, (d) MMP-9, and (e) MMP-12. Control: saline-treated mice; model: LPS and CS-exposed mice; low: JPYF II (0.75 g/kg/d) + LPS and CS-exposed mice; middle: JPYF II (1.5 g/kg/d) + LPS and CS-exposed mice; high: JPYF II (3 g/kg/d) + LPS and CS-exposed mice; dexamethasone: dexamethasone (2 mg/kg/d) + LPS and CS-exposed mice. Values are presented as means ± SD. ^#P < 0.05, ^##P < 0.01, and ^###P < 0.001 compared with control mice; < 0.05, < 0.01, and < 0.001 compared with LPS and CS-exposed mice.

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