The Role of Berberine in the Prevention of HIF-1α Activation to Alleviate Adipose Tissue Fibrosis in High-Fat-Diet-Induced Obese Mice

Figure 2

Effects of berberine on eWAT fibrosis of HFD-induced obese mice. Histological analysis of H&E staining of epididymal fat sections. Adipocyte area was analyzed by Image Pro Plus software ((a) and (b)). The deposition of collagen in epididymal white adipose tissue was determined by Masson trichrome staining (c, d) and Sirius Red staining (e, f). Data are shown as mean ± SEM (n=4). P < 0.01 versus NC group; < 0.05 versus HFD group; < 0.01 versus HFD group.

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