Review Article

Traditional Chinese Medicine Injections in the Treatment of Diabetic Foot: A Systematic Review and Meta-Analysis

Table 1

Basic characteristics of the included studies.

Study IDsSample sizeAgeInterventionDuration (weeks)Outcomes
(T/C)(T/C)TC

Chen 201830/3066.06 ± 0.47(62~82)/ 67.36 ± 0.55(64~84)Ginkgo biloba extract injection (20ml/d);
Basic care
Basic care4(1) Total effective rates;
(2) Hemorheology

Chi 201241/41NAErigeron Breviscapus extract injection (30ml/d);
Basic care
Basic care2(1) Total effective rates;
(2) Nerve conduction velocity;
(3) Hemorheology

Guo et al. 2017100/10043.1±3.4/44.3±3.7Ginkgo biloba extract injection (20ml/d);
Alprostadil (10μg/d);
Basic care
Alprostadil (10μg/d);
Basic care
4(1) Total effective rates;

Nuerzada et al. 201831/3172.5±9.5(63~82)/72.5±10.5(61~83)Ginkgo biloba extract injection (10ml/d);
Basic care
Basic careNA(1) Total effective rates;
(2) Hemorheology

He et al. 201040/3868±14.5/69±15.2Erigeron Breviscapus extract injection (30ml/d);
Basic care
Basic care2(1) Total effective rates;
(2) Nerve conduction velocity;
(3) Hemorheology

Jin et al. 201770/7062.79±5.43(53~78)/ 61.97±6.25(52~79)Compound Salvia Miltiorrhiza injection (20ml/d);
Alprostadil (10μg/d);
Basic care
Alprostadil (10μg/d);
Basic care
4(1) Total effective rates;
(2) Blood lipid levels;
(3) Renal function and urine protein

Lin 200836/3661.36(51~75)/
60.35±5.3(49~72)
Erigeron Breviscapus extract injection (400mg/d);
Basic care
Basic care2(1) Total effective rates;
(2) Hemorheology;
(3) Ulcer size

Liu 200837/3367(55~81)/
65(56~79)
Danhong injection (NA);
Anisodamine (20mg/d);
Basic care
Anisodamine (20mg/d);
Basic care
4(1) Total effective rates

Shi 201042/42(43~74)/
(38~66)
Compound Salvia Miltiorrhiza injection (12ml/d);
Ozagrel (160mg/d);
Basic care
Ozagrel (160mg/d);
Basic care
4(1) Total effective rates;
(2) Nerve conduction velocity;
(3) Hemorheology

Wang 201022/1857.6(38~73)/
56.2(41~71)
Danhong injection (20ml/d);
Basic care
Basic care4(1) Total effective rates;
(2) Hemorheology

Wen 201420/2061.8(38~76)/
63.8(36~75)
Panax notoginsenosides injection (250mg/d);
Basic care
Basic careNA(1) Total effective rates;
(2) Lower limbs blood

Wu et al. 200336/3663(48~72)/
62(46~68)
Compound Salvia Miltiorrhiza injection (10~30g/d);
Pancreatic kininogenase (480~720IU/d);
Mecobalamin (500~1000μg/d);
Basic care
Pancreatic kininogenase (480~720IU/d);
Mecobalamin (500~1000μg/d);
Basic care
4(1) Total effective rates;
(2) Nerve conduction velocity;
(3) Hemorheology

Xiang 201750/5058.91±8.54/
59.42±7.89
Danhong injection (40ml/d);
Basic care
Basic care4(1) Total effective rates;
(2) Ulcer area
(3) Arterial diameter and Blood velocity

Yu et al. 200825/2557.6(38~73)/
56.2(41~71)
Danhong injection (40ml/d);
Basic care
Basic care3(1) Total effective rates

Zhang et al. 200816/1652.3±2.5/
51.8±2.7
Danhong injection (20ml/d);
Basic care
Basic care4(1) Total effective rates;
(2) Nerve conduction velocity

Zheng et al. 201433/3358.2±5.3/
56.7±6.6
Danhong injection (30ml/d);
Basic care
Basic care4(1) Total effective rates;
(2) Oxidative stress status

Zhu 201030/16NAPanax notoginsenosides injection (450mg/d);
Basic care
Basic care1.7(10d)(1) Total effective rates