Moxibustion-Simulating Bipolar Radiofrequency Suppresses Weight Gain and Induces Adipose Tissue Browning via Activation of UCP1 and FGF21 in a Mouse Model of Diet-Induced Obesity

Figure 6

M-RF stimulation increases the level of FGF21 in serum and WAT of DIO mice. (a) ELISA for serum FGF21 in control (n = 5), RF-L (n = 5), RF-M (n = 5), and RF-H (n = 5). (b) Representative Western blotting for FGF21 in WATs of DIO mice in control (n = 5), RF-L (n = 5), RF-M (n = 5), and RF-H (n = 5). (c) Quantification of (b) and calculated in terms of ratio relative to control. Note that all three levels of M-RF stimulation significantly increased the level of FGF21 in serum and WAT compared to the control. Results are presented as the mean ± SD. , P < 0.05 versus control. , P < 0.01 versus control.

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