Confirming the Effects of Qinghuayin against Chronic Atrophic Gastritis and a Preliminary Observation of the Involved Inflammatory Signaling Pathways: An In Vivo Study

Figure 3

mRNA expression of TLR4, MyD88, NF-κB, and COX-2 in the different groups of rats. (a) The mRNA expression of the TLR4 signaling pathway. The mRNA expression of TLR4 in the model group (M) was significantly higher than that of those in the other groups. Treatment with low-dose QHY (M + LT) significantly downregulated the enhancement of the mRNA expression of TLR4 (p < 0.001); in contrast, treatment with high-dose QHY (M + HT) achieved significantly more reduction (p < 0.001). The high-dose and low-dose exerted significantly different effects (p < 0.05). (b) The mRNA expression of the MyD88 signaling pathway. (c) The mRNA expression of the NF-κB signaling pathway. (d) The mRNA expression of the COX-2 signaling pathway achieved results similar to those of TLR4 only in the NF-κB signaling pathway; there was no significant difference between the high- and low-dose QHY treatments. All the values represent mean ± standard deviation (SD); means P < 0.05, means P < 0.01, and means P < 0.001. HT = high-dose QHY treatment, LT = low-dose QHY treatment, and M = model mice without treatment.

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