Simultaneous Quantification of Gallic Acid, Bergenin, Epicatechin, Epicatechin Gallate, Isoquercitrin, and Quercetin-3-Rhamnoside in Rat Plasma by LC-MS/MS Method and Its Application to Pharmacokinetics after Oral Administration of Ardisia japonica Extract

Table 4

The recoveries and matrix effects of 6 compounds ().

Compounds	Concentration (ng/mL)	Recovery		Matrix effect
		Accuracy (%)	RSD (%)	Accuracy (%)	RSD (%)
Gallic acid	2	111	10.2	116	8.89
	6	111	6.76	113	3.52
	20	104	7.92	110	5.03
	200	106	8.50	99.7	9.08
Bergeninum	2	109	8.59	109	2.31
	6	108	12.6	112	14.2
	20	95.4	7.14	107	6.05
	200	91.0	10.2	115	9.46
L-Epicatechin	4	111	13.7	99.5	8.46
	12	105	11.3	102	11.6
	40	110	11.1	88.5	5.87
	400	92.4	6.49	92.0	6.95
(−)-Epicatechin gallate	2	109	6.58	113	10.4
	6	108	9.99	114	5.67
	20	109	9.76	108	7.24
	200	101	5.08	115	13.5
Isoquercitrin	1	103	10.2	112	1.72
	3	90.0	12.3	106	13.3
	10	107	8.03	113	8.65
	100	98.3	5.63	113	6.28
Quercetin-3-rhamnoside	0.4	104	10.9	110	10.1
	1.2	108	13.6	110	11.8
	4	89.6	3.14	110	11.9
	40	97.9	3.59	118	6.77
Ferulic acid	100	80.0	2.76	87.7	3.10
Puerarin	100	85.7	6.55	79.4	2.65
Warfarin	100	76.4	3.77	106	3.41