Research Article

Exploring the Pharmacological Mechanism of Danzhi Xiaoyao Powder on ER-Positive Breast Cancer by a Network Pharmacology Approach

Table 2

Cluster of herbal formula-disease PPI network.

ClusterScoreNodesEdgesGenes

130.48638564CCND1, STAT1, IGF1, MAP2K1, PIK3CA, BCL2, F2, PTK2, MYC, JAK2, RHOA, PIK3R1, BCL2L1, AKT2, NOS3, AKT1, IGF1R, HMOX1, MMP9, ABL1, KIT, RAF1, IL2, CDC42, GRB2, LCK, MMP2, KDR, ERBB2, ERBB3, STAT5B, RAC1, TP53, PTPN11, MAPK8, MTOR, FOXO3, MET

21652408Ergosterol peroxide, ethyl oleate (NF), PPARD, PAK1, PDPK1, EPHA2, EGF, RET, SYK, RARA, CCL2, WT1, YAP1, NOS2, glabridin, glycyrrhetinic acid, NME2, BRAF, ZAP70, PPARG, ESRRG, PPARA, HSP90AA1, HCK, CASP3, linoleyl acetate, longikaurin A, mairin, mandenol, CDK6, MOL000273, MOL001910, 508-02-1, 64997-52-0, 8β-ethoxy atractylenolide III, pachymic acid, paeonidanin, palbinone, ESR2, CSK, saikosaponin C, MDM2, PGR, beta-sitosterol, supraene, trametenolic acid, troxerutin, RORA, α-amyrin, FGF1, EGFR, NCOR2

310.4212099XIAP, ESR1, MAPK1, FGFR1, MAPK14, MMP1, RAC2, MYB, PTGS2, PTPN1, MAPK12, EIF4E, AR, SRC, ERBB4, INSR, JAK3, GSK3B, SIRT1, ALB

49.14343192NR1H2, F7, ferulic acid, MAPK10, BTK, MOL000285, RARG, 4-O-methylpaeoniflorin, APAF1, THRA, CASP1, GATA3, MUC1, PLK1, HSP90AB1, PRKACA, PLG, VDR, CTSD, RUNX1, glabrene, CHEK1, PRKCQ, LGALS3, poricoic acid A, glycyrrhizin, ITK, FGFR2, EZH2, RARB, HSPA8, TNFRSF11B, CASP7, sudan III, CA2, ZINC02816192, THRB, HRAS, HNF4G, kaempferol, TEK, licochalcone G, NCOA3

57.82936137APRT, IMPDH2, MMP3, NR3C1, NR1H3, ELANE, 7,9(11)-dehydropachymic acid, GMPR2, paeoniflorgenone, paeoniflorin sulfonate, PGF, areapillin, UMPS, quercetin, senkyunolide I, stigmasterol, ARF1, CALM2, DHFR, TGFB2, butylidenephthalide, isoliquiritigenin, (+)-anomalin, isorhamnetin, vestitol, crocetin, 113269-36-6, CANT1, α-spinasterol, ANXA5, NR1I2, ARHGAP1, licochalcone A, 113269-37-7, licoricone, MTHFD1

66.36839121MMP8, PARP1, GSTM1, RAN, PPP5C, 3β-acetoxyatractylone, PPIA, CYP2C8, CCNA2, HPRT1, GSS, SULT2A1, BIRC7, 113269-39-9, SETD7, EPHB4, DHODH, REN, GSTO1, petunidin, DPP4, DUT, OTC, GSTT2, ADK, DTYMK, CALM1, PAPSS1, TK1, IMPDH1, hederagenin, MKI67, CDK7, GSTA1, GSTP1, CTSB, AURKA, licochalcone B, MAPKAPK2

74.8483480Dehydroeburicoic acid, ergosta-7,22E-dien-3beta-ol, RAP2A, MOL000280, MOL000287, mudanpioside H, HDAC4, NSC684433, octalupine, 18103-41-8, RXRA, PLAU, formononetin, albiflorin, 1-methoxyphaseollidin, HSPD1, paeoniflorin, KAT2B, TOP2A, glycyrin, ammidin, poricoic acid B, poricoic acid C, CTNNA1, sainfuran, sitosterol, isoimperatorin, isolicoflavonol, cerevisterol, 3-methylkempferol, RND3, CDK2, licoisoflavone B, cubebin

84.7622250SDS, SHMT1, CTSG, AK1, ACE, TYMS, GMPR, MME, GP1BA, METAP2, DCK, PIP, (+)-catechin, ATIC, GART, FKBP1A, PSPH, CBS, ITGAL, NT5M, LYZ, PDE4D

93.5381423G6PD, RAB5A, ARF4, LDHB, BACE1, AHCY, PKLR, PYGL, RAB11A, HK1, ADAM17, GSR, MMP13, SOD2

103.33345GALK1, GPI, GCK, ME2

11333TPH1, CBR1, SPR