Evidence-Based Complementary and Alternative Medicine / 2018 / Article / Tab 5

Research Article

Syzygium jambos Displayed Antibacterial and Antibiotic-Modulating Activities against Resistant Phenotypes

Table 5

Resistance modulating effects of the leaves methanol extract from Syzygium jambos at its subinhibitory concentrations on selected S. aureus strains.

Antibiotics Bacterial strains, MIC (μg/mL) of antibiotics in the absence and presence of the extract
Extract concentrationATCC 25923MRSA3MRSA4MRSA9MRSA11MRSA12SA18SA36SA64Antibiotic modulating effect (%)

CIP08≤0.58≤0.512248
MIC/2≤0.5 (≥16)≤0.5 (na)4 (2)≤0.5 (na)≤0.5 (≥2)2 (1)≤0.5 (≥4)≤0.5 (≥8)8 (1)55.56
MIC/48 (1)≤0.5 (na)16 (0.5)≤0.5 (na)≤0.5 (≥2)2 (1)≤0.5 (≥4)≤0.5 (≥8)8 (1)33.33
CHL064644128128128812832
MIC/2≤2 (≥32)32 (2)4 (1)128 (1)64 (2)64 (2)≤2 (≥4)≤2 (≥64)16 (2)77.78
MIC/464 (1)64 (1)4 (1)128 (1)64 (2)64 (2)4 (2)≤2 (≥64)32 (1)44.44
TET0≤0.5322326464211
MIC/2≤0.5 (na)32 (1)≤0.5 (≥4)32 (1)32 (2)32 (2)≤0.5 (≥4)≤0.5 (≥2)≤0.5 (≥2)66.67
MIC/4≤0.5 (na)32 (1)≤0.5 (≥4)32 (1)32 (2)32 (2)1 (2)≤0.5 (≥2)≤0.5 (≥2)66.67
ERY01632168161632≤28
MIC/2≤2 (≥8)8 (4)4 (4)8 (1)16 (1)16 (1)≤2 (≥16)≤2 (na)≤2 (≥4)55.56
MIC/4≤2 (≥8)8 (4)4 (4)8 (1)16 (1)32 (0.5)≤2 (≥16)≤2 (na)8 (1)44.44
KAN0≤282561616648≤232
MIC/2≤2 (na)8 (1)256 (1)16 (1)16 (1)256 (0.25)≤2 (≥4)≤2 (na)32 (1)11.11
MIC/4≤2 (na)8 (1)256 (1)16 (1)16 (1)256 (0.25)4 (2)≤2 (na)32 (1)11.11
CEF0-------32128
MIC/2-------4 (8)8 (16)22.22
MIC/4-------16 (2)64 (2)22.22
STR025612864128646412812816
MIC/2≤2 (≥128)64 (2)64 (1)64 (2)32 (2)64 (1)4 (32)≤2 (≥64)16 (1)66.67
MIC/4256 (1)64 (2)64 (1)64 (2)64 (1)64 (1)4 (32)≤2 (≥64)16 (1)44.44
AMP0--256---128256-
MIC/2--256 (1)---128 (1)≤2 (≥128)-11.11
MIC/4--256 (1)---128 (1)256 (1)-0

TET: tetracycline, KAN: kanamycin, ERY: erythromycin, CHL: chloramphenicol, CIP: ciprofloxacin, AMP: ampicillin, STR: streptomycin, CEF: cefepime; (-): MIC not detected at up to 256 g/mL; (): modulating factor; na: not applicable; MIC: minimum inhibitory concentration; percentage of antibiotic’s modulating effect by the plant extracts; values in bold represent modulating factor ≥ 2 and modulating effect observed on more than 70% of the tested MDR bacteria.