Evidence-Based Complementary and Alternative Medicine / 2018 / Article / Tab 8

Research Article

Syzygium jambos Displayed Antibacterial and Antibiotic-Modulating Activities against Resistant Phenotypes

Table 8

Resistance modulating effects of the bark methanol extract from Syzygium jambos at its subinhibitory concentrations on selected MDR Gram-negative bacteria.

AntibioticsExtract
concentration
Bacteria, MIC (μg/mL), and modulating factors (in bracket)Antibiotic modulating
effect (%)
E. coliE. aerogenesK. pneumoniaeP. stuartiiP. aeruginosa
AG102AG100AtetEA27EA289KP55KP63PS2636NEA16PA01PA 124

CHL06486464646432646432
MIC/216 (4)8 (4)64 (1)64 (1)64 (1)16 (4)8 (4)32 (2)64 (1)32 (1)50.00
MIC/432 (2)16 (2)64 (1)64 (1)64 (1)32 (2)16 (2)32 (2)64 (1)32 (1)50.00
KAN03241632646416321664
MIC/232 (1)4 (1)4 (4)8 (1)64 (1)64 (1)2 (4)16 (2)4 (4)16 (4)50.00
MIC/432 (1)4 (1)4 (4)8 (1)64 (1)64 (1)4 (4)16 (2)16 (1)32 (2)40.00
STP01282562566464256256166464
MIC/232 (4)64 (4)64 (4)128 (1)32 (2)256 (1)256 (1)8 (2)64 (1)64 (1)50.00
MIC/4128 (1)256 (1)64 (4)128 (1)32 (2)128 (2)256 (1)16 (1)64 (1)64 (1)30.00
CIP0811184162216
MIC/28 (1)<0.5 (≥2)1 (1)0.5 (2)16 (1)0,5 (2) <0,5 (≥32)1 (2)0.5 (4)4 (4)70.00
MIC/48 (1)1 (1)1 (1)1 (1)16 (1)0,5 (2)0,5 (32)1 (1)1 (2)4 (4)40.00
TET08<0,5643216324321616
MIC/24 (2)<0,5 (na)64 (1)8 (4)16 (1)4 (8)<0,5 (≥8)2 (16)2 (8)8 (2)70.00
MIC/44 (2) <0,5 (na)64 (1)8 (4)16 (1)16 (2) <0,5 (≥8)8 (4)2 (8)16 (1)50.00
ERY06481664643216321632
MIC/24 (2)<0,5 (≥16)64 (1)8 (4)16 (1)4 (8)<0,5 (≥8)2 (16)8 (2)16 (2)80.00
MIC/44 (2)<0,5 (≥16)64 (1)8 (4)16 (1)16 (2)<0,5 (≥8)8 (4)16 (1)16 (2)70.00

TET: tetracycline, KAN: kanamycin, ERY: erythromycin, CHL: chloramphenicol, CIP: ciprofloxacin, AMP: ampicillin STR: streptomycin, CEF: cefepime; (-): MIC not detected at up to 256 g/mL; (): modulating factor; na: not applicable; MIC: minimum inhibitory concentration; percentage of antibiotic’s modulating effect by the plant extracts; values in bold represent modulating factor ≥ 2 and modulating effect observed on more than 70% of the tested MDR bacteria.