The Herb-Drug Interaction of Clopidogrel and Xuesaitong Dispersible Tablet by Modulation of the Pharmacodynamics and Liver Carboxylesterase 1A Metabolism

Table 3

Pharmacokinetic parameters of CAMD after intragastric administration of clopidogrel alone or coadministration of clopidogrel and XST to rats.

Parameter	Clopidogrel group()	Combination group()
(h)
(ng/mL)
(h)
(h)
Vd/F (L)
CL/F (L/h)
T1/2

(h): time to reach maximum concentration; (ng/mL): maximum plasma concentration; AUC: the area under the concentration time curve; : from time zero to infinity; : from time zero to 24 h; MRT(h): mean residence time; Vd/F (L): apparent distribution volume; CL/F (L/h): apparent clearance; T_1/2: the half-life of drug elimination during the terminal phase. P<0.05 compared with related parameter of CAMD in the alone group.