Research Article

Danhong Injection Alleviates Mechanical Allodynia via Inhibiting ERK1/2 Activation and Elevates BDNF Level in Sciatic Nerve in Diabetic Rat

Figure 3

Effect of intrathecal U0126 infusion on mechanical allodynia caused by DPN and confirmation of the inhibition of ERK1/2 activation in spinal cord by intrathecal U0126 injection. (a) 50% paw withdraw thresholds in vehicle and U0126 treated groups. (b) Representative western blot result of p-ERK1/2 and t-ERK1/2. (c) Phosphorylated ERK1/2 level was first corrected for by total ERK1/2 level and expressed as % DPN + vehicle. versus DPN + vehicle group. .
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