Pharmacological Evaluation of Mentha spicata L. and Plantago major L., Medicinal Plants Used to Treat Anxiety and Insomnia in Colombian Caribbean Coast

Figure 2

Evaluation of the anxiolytic effect of the aqueous extract obtained from M. spicata and P. major. The influence of M. spicata (1000 mg/Kg, p.o.); P. major (1000 mg/Kg, p.o.); and diazepam (DZP, 1 mg/Kg, i.p.) was assessed by the entries into open arms (a) and the percentage of time spent in the open arms (b) of the Elevated Plus-Maze (EPM) apparatus. Results are expressed as mean ± S.E.M. (n=10). P<0.0001, P<0.01, and P<0.05 ANOVA are significantly different compared with the control group.

(a)

(b)