Xijiao Dihuang Decoction Alleviates Ischemic Brain Injury in MCAO Rats by Regulating Inflammation, Neurogenesis, and Angiogenesis

Table 1

The identified phytochemical compounds in Xijiao Dihuang Decoction (XDD) detected by UHPLC-MS.

Peak no.	Identity	(min)	Mean measure mass (Da)	Theoretical exact mass (Da)	Mass accuracy (ppm)	Empirical formula and proposed adduct ions or fragment ions
	catalpol	1.30	407.1194	407.1190	1.0	M-H+HCOOH
			361.1136	361.1135	0.3	M-H
2	1′-O-galloylsucrose, 6′-O-galloylsucrose and 6-O-galloylsucrose	1.60	493.1207	493.1193	2.8	M-H
3	Gallic acid	2.07	169.0140	169.0137	1.8	M-H
6	1′-O-galloylsucrose, 6′-O-galloylsucrose and 6-O-galloylsucrose	2.39	493.1194	493.1193	0.2	M-H
7	1′-O-galloylsucrose, 6′-O-galloylsucrose and 6-O-galloylsucrose	2.58	493.1191	493.1193	-0.4	M-H
9	Oxypaeoflorin sulfonate	3.04	559.1113	559.1122	-1.6	SM-H
10	Lamiidol	3.32	393.1396	393.1397	-0.3	M-H
14	Paeoniflorin sulfonate	4.29	543.1177	543.1197	-3.7	M-H
15	Oxypaeoflorin isomer	4.51	495.1501	495.1503	-0.4	M-H
16	Oxypaeoflorin	4.79	495.1500	495.1503	-0.6	M-H
17	(+)-Catechin	4.94	289.0712	289.0712	0.0	M-H
18	Mudanpioside E	5.15	525.1607	525.1608	-0.2	M-H
21	Purpureaside C/Echinacoside	5.84	785.2502	785.2504	-0.3	M-H
22	Albiflorin	6.00	479.1556	479.1553	0.6	M-H
			525.1621	525.1608	2.5	M-H+HCOOH
24	Paeoniflorin	6.31	479.1549	479.1553	-0.8	M-H
			525.1616	525.1608	1.5	M-H+HCOOH
30	Isoacteoside/Acteoside/Forsythoside A	7.13	623.1976	623.1976	0.0	M-H
31	Galloyl paeoniflorin/Galloylabiflorin/their isomer	7.28	631.1662	631.1663	-0.2	M-H
35	iso-Mudanpioside E	7.68	615.1703	615.1714	-1.8	M-H
36	Galloyl paeoniflorin/Galloylabiflorin/their isomer	7.77	631.1653	631.1663	-1.6	M-H
38	Isopaeoniflorin or Albiflorin R1	8.23	479.1546	479.1553	-1.5	M-H
41	unknown	8.62	507.1490	507.1503	-2.6	M-H
42	Benzoyloxypaeoflorin	8.84	599.1762	599.1765	-0.5	M-H
45	Mudanoside C	9.21	599.1779	599.1765	2.3	M-H
46	Benzoyl paeoniflorin	10.45	629.1872	629.1870	0.3	M-H
47	Benzoyl paeoniflorin isomer	10.63	629.1866	629.1870	-0.6	M-H