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Evidence-Based Complementary and Alternative Medicine
Volume 2018, Article ID 5952707, 10 pages
https://doi.org/10.1155/2018/5952707
Research Article

Effect of Resveratrol Dry Suspension on Immune Function of Piglets

1Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
2College of Science, Sichuan Agricultural University, Ya’an 625014, China
3College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China

Correspondence should be addressed to Zhongqiong Yin; moc.361@qgnohzniy

Received 20 September 2017; Accepted 10 January 2018; Published 1 February 2018

Academic Editor: Randhir Singh Dahiya

Copyright © 2018 Qiuting Fu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Resveratrol, a polyphenolic plant antitoxin, has a wide range of pharmacological activities. In this study, we systematically evaluated the effects of resveratrol dry suspension (RDS) on immune function in piglets that were treated with different doses of RDS for 2 weeks. The results showed that the RDS has significant effects on the development, maturation, proliferation, and transformation of T lymphocytes. RDS could regulate humoral immune responses by upregulating the release of IFN-γ and downregulating the release of TNF-α. After piglets were vaccinated against classical swine fever virus and foot-and-mouth disease virus, the antibody titers were significantly increased. RDS treatment showed an excellent resistance to enhance T-SOD activity. Values of blood routine and blood biochemistry showed no toxicity. These results suggested that RDS could be considered as an adjuvant to enhance immune responses to vaccines, as well as dietary additives for animals to enhance humoral and cellular immunity.