Immunomodulatory Effects of Kuseonwangdogo-Based Mixed Herbal Formula Extracts on a Cyclophosphamide-Induced Immunosuppression Mouse Model

Figure 3

Serum IFN-γ levels in intact or CPA-induced immunosuppressive mice. Significant decreases of serum IFN-γ levels were noticed in CPA control mice as compared with intact vehicle control, respectively. All three different dosages of MHFe showed significant and clear dose-dependent increases of serum IFN-γ levels as compared with CPA control mice, respectively. In addition, β-glucan 250 mg/kg administered mice also showed increases of serum IFN-γ levels comparable to those of equal dosages of MHFe administered mice, in this study; values are expressed mean ± SD of eight mice; CPA: cyclophosphamide; MHFe: two-sweetener-excluded Kuseonwangdogo-based mixed herbal formula aqueous extracts; IFN: interferon; as compared with intact control mice by LSD test; as compared with CPA control mice by LSD test.