A Network Pharmacology-Based Approach to Investigate the Novel TCM Formula against Huntington’s Disease and Validated by Support Vector Machine Model

Table 4

Top 10 pharmacophore models of CK2A2 inhibitors generated by HypoGen protocol.

Hypothesis	Total cost	Correlation	Error	RMS	Feature
Hypo 1	185.455	0.7584	168.342	1.62	HBA,HBD,HY,RING
Hypo 2	186.266	0.7513	169.514	1.64	HBA,HBD
Hypo 3	187.455	0.7463	170.365	1.655	HBA,HBD,HY
Hypo 4	187.478	0.7457	170.459	1.656	HBA,HBD,HY,RING
Hypo 5	187.622	0.743	170.899	1.663	HBA,HBD,HY
Hypo 6	187.69	0.7454	170.518	1.657	HBA,HBD,HY,RING
Hypo 7	187.872	0.7434	170.854	1.663	HBA,HBD
Hypo 8	187.973	0.7488	169.985	1.648	HBA,HBD,HY,RING
Hypo 9	188.302	0.7432	170.898	1.663	HBA,HBD,HY,RING
Hypo 10	188.414	0.7421	171.08	1.667	HBA,HBD,HY,RING

a. Cost value: Null cost = 232.267, Fix cost = 137.8, and configure cost = 15.5857.
b. Feature description: HBA, HBD, HY, and RING indicate hydrogen bond acceptor, hydrogen bond donor, hydrophobic, and Ring aromatic, respectively.