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Evidence-Based Complementary and Alternative Medicine
Volume 2018, Article ID 6139372, 13 pages
https://doi.org/10.1155/2018/6139372
Research Article

The Protective Effect of Total Flavones from Rhododendron simsii Planch. on Myocardial Ischemia/Reperfusion Injury and Its Underlying Mechanism

1Department of Pharmacology, Anhui Medical University, Hefei, Anhui 230032, China
2Anhui Academy of Medical Sciences, Hefei, Anhui 230061, China
3Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China

Correspondence should be addressed to Gong Peng; moc.361@ko.8002gnepgnog and Zhi-Wu Chen; moc.361@wzmrahphc

Received 28 August 2017; Accepted 25 October 2017; Published 9 January 2018

Academic Editor: Christian Lehmann

Copyright © 2018 Sheng-Yong Luo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. S. Ames, H. M. Sarau, J. K. Chambers et al., “Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14,” Nature, vol. 401, no. 2, pp. 282–286, 1999. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Mori and M. Fujino, “Urotensin II-related peptide, the endogenous ligand for the urotensin II receptor in the rat brain,” Peptides, vol. 25, no. 10, pp. 1815–1818, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. J.-Y. Zhang, Z.-W. Chen, and H. Yao, “Protective effect of urantide against ischemia-reperfusion injury via protein kinase C and phosphtidylinositol 3-kinase - Akt pathway,” Canadian Journal of Physiology and Pharmacology, vol. 90, no. 5, pp. 637–645, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. C. H. Park, J. H. Lee, M. Y. Lee, J. H. Lee, B. H. Lee, and K.-S. Oh, “A novel role of G protein-coupled receptor kinase 5 in urotensin II-stimulated cellular hypertrophy in H9c2UT cells,” Molecular and Cellular Biochemistry, vol. 422, no. 1-2, pp. 151–160, 2016. View at Publisher · View at Google Scholar · View at Scopus
  5. Ö. Şatiroǧlu, M. E. Durakoǧlugil, M. Çetin, Y. Çiçek, T. Erdoǧan, and H. Duman, “The role of urotensin II and atherosclerotic risk factors in patients with slow coronary flow,” Interventional Medicine and Applied Science, vol. 8, no. 4, pp. 158–163, 2016. View at Publisher · View at Google Scholar · View at Scopus
  6. K.-S. Oh, J. H. Lee, K. Y. Yi et al., “A novel urotensin II receptor antagonist, KR-36996, improved cardiac function and attenuated cardiac hypertrophy in experimental heart failure,” European Journal of Pharmacology, vol. 799, pp. 94–102, 2017. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Gonzalez, N. Valls, R. Brito, and R. Rodrigo, “Essential hypertension and oxidative stress: New insights,” World Journal of Cardiology, vol. 6, pp. 353–366, 2014. View at Google Scholar
  8. C.-Z. Chiu, B.-W. Wang, and K.-G. Shyu, “Angiotensin II and the JNK pathway mediate urotensin II expression in response to hypoxia in rat cardiomyocytes,” Journal of Endocrinology, vol. 220, no. 3, pp. 233–246, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Gong, Z. Chen, X. Zhang et al., “Urotensin II protects cardiomyocytes from apoptosis induced by oxidative stress through the CSE/H2S pathway,” International Journal of Molecular Sciences, vol. 16, no. 6, pp. 12482–12498, 2015. View at Publisher · View at Google Scholar
  10. D. Ç. Akkoyun, A. Akyüz, Ş. Alpsoy et al., “Plasma urotensin II and neurokinin B levels in acute myocardial infarction and stable coronary artery disease,” Anadolu Kardiyoloji Dergisi, vol. 15, no. 8, pp. 628–633, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. H. Shimokawa, S. Sunamura, and K. Satoh, “RhoA/Rho-Kinase in the cardiovascular system,” Circulation Research, vol. 118, no. 2, pp. 352–366, 2016. View at Publisher · View at Google Scholar · View at Scopus
  12. X. Yu, Q. Zhang, Y. Zhao et al., “Activation of G protein-coupled estrogen receptor 1 induces coronary artery relaxation via Epac/Rap1-mediated inhibition of RhoA/Rho kinase pathway in parallel with PKA,” PLoS ONE, vol. 12, no. 3, Article ID e0173085, 2017. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Ming, L. Songyan, C. Yawen et al., “trans-Polydatin protects the mouse heart against ischemia/reperfusion injury via inhibition of the renin–angiotensin system (RAS) and Rho kinase (ROCK) activity,” Food Funct., vol. 8, no. 6, pp. 2309–2321, 2017. View at Publisher · View at Google Scholar
  14. L. Tran, A. R. Kompa, W. Kemp, A. Phrommintikul, B. H. Wang, and H. Krum, “Chronic urotensin-II infusion induces diastolic dysfunction and enhances collagen production in rats,” American Journal of Physiology-Heart and Circulatory Physiology, vol. 298, no. 2, pp. H608–H613, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Luo, S. Chen, Y. Qin, Z. Chen, and F. Gallyas, “Urotensin-II receptor antagonist SB-710411 protects rat heart against ischemia-reperfusion injury via RhoA/ROCK pathway,” PLoS ONE, vol. 11, no. 1, Article ID e0146094, 2016. View at Publisher · View at Google Scholar
  16. Y. Jiao, Y.-F. Fan, Y.-L. Wang, J.-Y. Zhang, S. Chen, and Z.-W. Chen, “Protective effect and mechanism of total flavones from Rhododendron simsii planch flower on cultured rat cardiomyocytes with anoxia and reoxygenation,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 863531, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Huang, P. Yin, and D. F. Jiang, “Quality standard of rhododendron flos,” World Science and Technology, vol. 16, no. 1, pp. 151–155, 2014. View at Google Scholar
  18. S. J. Dai, R. Y. Chen, and D. Q. Yu, “Studies on the flavonoid compounds of Rhododendron Anthopogonoids,” China J. Chin. Mat. Med, vol. 29, pp. 44-45, 2004. View at Google Scholar
  19. L. P. Yuan, Z. W. Chen, F. Li, L. Y. Dong, and F. H. Chen, “Protective effect of total flavones of rhododendra on ischemic myocardial injury in rabbits,” American Journal of Chinese Medicine, vol. 34, no. 3, pp. 483–492, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Han, G. W. He, and Z. W. Chen, “Protective effect and mechanism of total flavones from Rhododendron simsii planch on endothelium-dependent dilatation and hyperpolarization in cerebral ischemia-reperfusion and correlation to hydrogen sulphide release in rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 904019, 11 pages, 2014. View at Publisher · View at Google Scholar
  21. J. Jiang, X. Yuan, T. Wang et al., “Antioxidative and cardioprotective effects of total flavonoids extracted from Dracocephalum moldavica L. against acute ischemia/reperfusion-induced myocardial injury in isolated rat heart,” Cardiovascular Toxicology, vol. 14, no. 1, pp. 74–82, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Akhmedov, F. Montecucco, V. Braunersreuther et al., “Genetic deletion of the adaptor protein p66Shc increases susceptibility to short-term ischaemic myocardial injury via intracellular salvage pathways,” European Heart Journal, vol. 36, no. 8, pp. 516–526, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. W. Gao, B. Zhao, L. Liu, Q. Yuan, X. Wu, and Z. Xia, “Myocardial ischemic post-conditioning protects the lung against myocardial ischemia/reperfusion-induced damage by activating GSK-3β,” Acta Cirurgica Brasileira, vol. 32, no. 5, pp. 376–387, 2017. View at Publisher · View at Google Scholar
  24. Y. Liu, H. Yang, L. Song et al., “AGGF1 protects from myocardial ischemia/reperfusion injury by regulating myocardial apoptosis and angiogenesis,” Apoptosis, vol. 19, no. 8, pp. 1254–1268, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. Z. Chen, D. R. Spahn, X. Zhang, Y. Liu, H. Chu, and Z. Liu, “Morphine Postconditioning Protects Against Reperfusion Injury: The Role of Protein Kinase C-Epsilon, Extracellular Signal-Regulated Kinase 1/2 and Mitochondrial Permeability Transition Pores,” Cellular Physiology and Biochemistry, vol. 39, no. 5, pp. 1930–1940, 2016. View at Publisher · View at Google Scholar · View at Scopus
  26. C. Zhou, J. Bai, C. Jiang, L. Ye, Y. Pan, and H. B. Zhang, “Geranylgeranylacetone attenuates myocardium ischemic/reperfusion injury through HSP70 and Akt/GSK-3β/eNOS pathway,” American Journal of Translational Research, vol. 9, no. 2, Article ID AJTR0036151, pp. 386–395, 2017. View at Google Scholar · View at Scopus
  27. K. Riches, P. Warburton, D. J. O'Regan, N. A. Turner, and K. E. Porter, “Type 2 diabetes impairs venous, but not arterial smooth muscle cell function: possible role of differential RhoA activity,” Cardiovascular Revascularization Medicine, vol. 15, no. 3, pp. 141–148, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. D. G. Lambert, “Urotensin II: From osmoregulation in fish to cardiovascular regulation in man,” British Journal of Anaesthesia, vol. 98, no. 5, pp. 557–559, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Bell, N. Sopko, H. Matsui, J. Hannan, and T. Bivalacqua, “RhoA/ROCK activation in major pelvic ganglion mediates caspase-3 dependent nitrergic neuronal apoptosis following cavernous nerve injury,” Neural Regeneration Research, vol. 12, no. 4, pp. 572-573, 2017. View at Publisher · View at Google Scholar
  30. S. Crestani, R. C. Webb, and J. E. da Silva-Santos, “High-Salt Intake Augments the Activity of the RhoA/ROCK Pathway and Reduces Intracellular Calcium in Arteries From Rats,” American Journal of Hypertension, vol. 30, no. 4, pp. 389–399, 2017. View at Publisher · View at Google Scholar
  31. H. Zhang, L. Shi, B. Wan et al., “Dihydrotestosterone modulates endothelial progenitor cell function via RhoA/ROCK pathway,” American Journal of Translational Research, vol. 8, no. 10, pp. 4300–4309, 2016. View at Google Scholar
  32. T. Skaria, E. Bachli, and G. Schoedon, “Wnt5A/Ryk signaling critically affects barrier function in human vascular endothelial cells,” Cell Adhesion & Migration, vol. 11, no. 1, pp. 24–38, 2017. View at Publisher · View at Google Scholar · View at Scopus
  33. M.-Y. Liu, J. Jin, S.-L. Li et al., “Mitochondrial fission of smooth muscle cells is involved in artery constriction,” Hypertension, vol. 68, no. 5, pp. 1245–1254, 2016. View at Publisher · View at Google Scholar · View at Scopus
  34. L. Wei, M. Surma, G. Gough et al., “Dissecting the mechanisms of doxorubicin and oxidative stress-induced cytotoxicity: The involvement of actin cytoskeleton and ROCK1,” PLoS ONE, vol. 10, no. 7, Article ID e0131763, 2015. View at Publisher · View at Google Scholar · View at Scopus
  35. C. R. Sunico, D. González-Forero, G. Domínguez, J. M. García-Verdugo, and B. Moreno-López, “Nitric oxide induces pathological synapse loss by a protein kinase G-, Rho kinase-dependent mechanism preceded by myosin light chain phosphorylation,” The Journal of Neuroscience, vol. 30, no. 3, pp. 973–984, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. K. He, L. Yan, C.-S. Pan et al., “ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia-reperfusion-induced myocardial injury,” American Journal of Physiology-Heart and Circulatory Physiology, vol. 307, no. 12, pp. H1764–H1776, 2014. View at Publisher · View at Google Scholar · View at Scopus