Use of Jianpi Jiedu Herbs in Patients with Advanced Colorectal Cancer: A Systematic Review and Meta-Analysis

Table 1

Characteristics of 12 included trials.

Study ID	Age (yrs)	Sample size (T/C)	Gender (M/F)	Study design (E/C)	Intervention		Treatment session	Main outcomes
					Control group	Experiment group
Lai, 2012, China [24]	30–73	30/30	38/22	Parallel-group	FOLFOX4	FOLFOX4 + CHM	8 weeks	Tumor response, AEs, KPS
Fan, 2013, China [25]	48–73	20/20	22/48	Parallel-group	L-OHP + S-1	L-OHP + S-1 + CHM	3 weeks	Tumor response, AEs, KPS, CM symptoms score, therapeutic effect of CM symptoms
Zhao, 2015, China [26]	48–67	30/30	39/21	Parallel-group	FOLFIRI	FOLFIRI + CHM	6 weeks	AEs, KPS, therapeutic effect of CM symptoms, QLQ-C30, serum CEA and CA199
Zhang, 2009, China [27]	44–70	20/20	22/18	Parallel-group	OLF	OLF + CHM	6 weeks	Tumor response, AEs, KPS, therapeutic effect of CM symptoms, FACT-C, serum CEA
Yuan, 2010, China [28]	48–71	15/15	12/18	Parallel-group	FOLFOX	FOLFOX + CHM	8 weeks	Tumor response, AEs, KPS, therapeutic effect of CM symptoms, QLQ-C30
Zhu, 2012, China [29]	49–71	20/20	32/08	Parallel-group	FOLFIRI	FOLFIRI + CHM	6 weeks	Tumor response, AEs, KPS, therapeutic effect of CM symptoms, serum CEA
Zhang et al., 2013, China [30]	50–78	30/30	31/29	Parallel-group	Capecitabine	Capecitabine + CHM	6 weeks	Tumor response, CM symptoms score, therapeutic effect of CM symptoms, AEs, EOTRC-QLQ-C30
Zhang et al., 2010, China [31]	NA	21/20	NA	Parallel-group	FOLFOX4	FOLFOX4 + CHM	4 weeks	Tumor response, AEs, KPS
Zhang et al., 2015, China [32]	NA	95/87	105/77	Parallel-group	FOLFIRI/XELOX/; FOLFOX4/FOLFOX6	FOLFIRI/XELOX/FOLFOX4/; FOLFOX6 + CHM	NA	Tumor response, AEs, KPS
Li, 2010, China [33]	25–70	26/25	14/37	Parallel-group	OLF	OLF + CHM	6 weeks	AEs, KPS, FACT-C, QOL, serum CEA and CA199
Zhu et al., 2016, China [34]	34–73	27/27	36/18	Parallel-group	mFOLFOX6	mFOLFOX6 + CHM	8 weeks	Tumor response, AEs, KPS
Yao and Ren, 2014, China [35]	47–72	21/21	22/20	Parallel-group	XELOX	XELOX + CHM	6 weeks	Tumor response, KPS, CM symptoms score, therapeutic effect of CM symptoms

Notes. E/C: experiment group/control group; M/F: male/female; CHM: Chinese herbal medicine; N/V: nausea and vomiting; NA: not available; AEs: adverse events; QOL: quality of life; FACT-P: functional assessment of cancer therapy-prostate; QLQ-C: quality of life questionnaire-cancer; KPS: Karnofsky performance score.