Evidence-Based Complementary and Alternative Medicine

Review Article

Effectiveness and Safety of Compound Chinese Medicine plus Routine Western Medicine in In-Stent Restenosis: A Meta-Analysis and Systematic Review

Table 2

Descriptive summary of treatment parameters of included studies.


Author, year	Intervention			Treatment course (mos)	Follow-up (mos)	outcomes
Author, year	CG		EG	Treatment course (mos)	Follow-up (mos)	outcomes

DAI GF 2017	RWM:	Clopidogrel P.O. 75 mg qd, Aspirin P.O. 0.1g qd, Atorvastatin P.O. 20 mg qd.	RWM plus Tongmai decoction P.O. 100 ml bid	6	6	ISR, Response rate of ECG

ZHANG RZ 2017	RWM:	Clopidogrel P.O. 75 mg qd, Aspirin P.O. 0.1 g qd, Atorvastatin P.O. 20 mg qd.	RWM plus Huoxue Tongluo capsule P.O. 4 pills tid	6	6	ISR, Response rate of ECG

WANG KL 2016	RWM:	Clopidogrel P.O. 75 mg qd, Aspirin P.O. 0.1 g qd, Metoprolol tartrate P.O. 12.5 mg bid, Atorvastatin P.O. 10 mg qd.	RWM plus Huxinkang tablets P.O. 10 pills tid	6	6	ISR, Response rate of ECG

GONG XY 2016	RWM:	Clopidogrel P.O. 75 mg qd, Aspirin P.O. 100 mg qd.	RWM plus Huoxue tongmai decoction P.O. 150 ml bid	6	6	ISR

TANG YY 2016	RWM:	Clopidogrel P.O. 75 mg qd, Aspirin P.O. 0.1 g qd.	RWM plus Yiqi tongluo huatan decoction P.O. 1 dose bid	6	6	ISR

ZHOU JC 2016	RWM:	Clopidogrel P.O. 75 mg qd, Aspirin P.O. 0.1g qd, Atorvastatin P.O. 20 mg qd.	RWM plus Qiwei sanxiong decoction P.O. 1/2 dose bid	6	6	ISR

ZHU HB 2016	RWM:	Clopidogrel P.O. 75 mg qd, Aspirin P.O. 0.5 g qd, Metoprolol tartrate P.O. 75 mg qd, Atorvastatin P.O. 10 mg qd.	RWM plus Mailuotong capsule P.O. 0.84 g tid.	6	6	ISR, Response rate of ECG

XIAO NH 2016	RWM:	Aspirin, Clopidogrel, ACEI/ARB, Beta blocker, Rosuvastatin P.O. 10 mg qd,	RWM plus Xinxuetong capsule P.O. 2 pills tid.	6	6	ISR
XIAO NH 2016	Plus placebo P.O. 2 pills tid.		RWM plus Xinxuetong capsule P.O. 2 pills tid.	6	6	ISR

REN DD 2016	RWM:	Clopidogrel P.O. 75 mg qd, Aspirin P.O. 0.1 g qd, Metoprolol tartrate P.O. 25 mg bid, Rosuvastatin P.O. 10 mg qd.	RWM plus Huoxue tongmai decoction P.O. 200 ml bid.	6	6	ISR
LI QZ 2016	RWM:	Clopidogrel P.O.75 mg qd, Aspirin P.O. 100 mg qd, Atorvastatin P.O. 10 mg qd.	RWM plus Guanxin tongluo capsule P.O. 1.6 g tid	6	6	ISR, Response rate of ECG

SUN QY 2016	RWM:	Aspirin P.O. 100 mg qd, Benazepril hydrochloride P.O. 10 mg qd, Clopidogrel P.O. 75 mg qd, Isosorbide mononitrate P.O. 25 mg tid, Metoprolol tartrate P.O. 12.5 mg bid, Simvastatin P.O. 10 mg qd.	RWM plus Yixin tongmai decoction P.O. 1/2 dose bid.	6	6	ISR

XU MT 2016	RWM:	Clopidogrel P.O. 75 mg qd, Aspirin P.O. 0.1 g qd, Atorvastatin P.O. 10 mg qd	RWM plus Guanxin suhe wan P.O. 30 g tid.	6	6	ISR

MENG XL 2016	RWM:	Clopidogrel P.O. 75 mg qd, Aspirin P.O. 0.1 g qd, Atorvastatin P.O. 20 mg qd, Valsartan P.O. 80 mg qd, Metformin P.O. 0.5 g bid.	RWM plus Yiqi Huoxue Jiedu decoction P.O. 300 ml bid.	6	6	ISR, Angina recurrence

YANG TL 2016	RWM:	Aspirin P.O. 100 mg qd, Clopidogrel P.O. 75 mg qd, pioglitazone 30 mg/d, ACEI/ARB, Beta blocker, Statins.	RWM plus Tongxinluo capsule P.O. 1.04 g tid.	12	12	ISR, CD, Angina recurrence, MI, MLD, LLL
YANG TL 2016	plus placebo P.O. 1.04 g tid.		RWM plus Tongxinluo capsule P.O. 1.04 g tid.	12	12	ISR, CD, Angina recurrence, MI, MLD, LLL

WANG X 2016	RWM:	Aspirin P.O.100 mg qd, Clopidogrel P.O. 75 mg qd, Atorvastatin P.O. 20 mg qd, Isosorbide mononitrate P.O. 40 mg qd, Metoprolol P.O. 23.75 mg qd.	RWM plus Huoxue yiqi tongmai decoction 100 ml bid.	6	6	ISR, MI, PCI, MLD, Angina recurrence

ZHOU W 2015	RWM:	Clopidogrel P.O. 75 mg qd, Aspirin P.O.0.1 g qd, Simvastatin P.O. 20 mg qd, Glyceryl trinitrate P.O. 0.5 mg prn.	RWM plus Longzhi dispensing granules P.O. 36 g tid.	6	6	ISR
PENG WD 2015	RWM:	Clopidogrel P.O. 75 mg qd, Aspirin P.O. 0.5 g qd, Atorvastatin P.O. 10 mg qd, Metoprolol tartrate P.O. 75 mg qd.	RWM plus Mailuo shutong capsule P.O. 0.84 g tid	6	6	ISR, Response rate of ECG

ZHANG Y 2015	RWM:	Aspirin, Clopidogrel, Nitrates, ACEI, Beta blocker, Statins.	RWM plus No. 1 Xintong prescription P.O. 100 ml bid.	6	6	ISR

WANG K 2015	RWM:	Clopidogrel P.O. 75 mg qd, Aspirin P.O. 100 mg qd, Atorvastatin P.O. 40 mg qd, Metoprolo P.O. 25 mg qd.	RWM plus Xuefu zhuyu capsule P.O. 3 pills tid.	12	12	ISR, CD, Angina recurrence

LU HW 2014	RWM:	Aspirin, Clopidogrel, Nitrates, ACEI, Beta blocker, Statins, CCB.	RWM plus Tongxinluo capsule P.O. 3 pills tid.	12	12	ISR, CD, MI, LLL, Angina recurrence

ZHANG PF 2014	RWM:	Clopidogrel P.O. 75 mg qd, Atorvastatin P.O. 20 mg qd, Metoprolol tartrate P.O. 12.5 mg bid.	RWM plus Xinmai futong decoction P.O. 1/2 dose bid.	6	6	ISR, LLL, Angina recurrence

SHI QJ 2014	RWM:	Clopidogrel P.O. 75 mg qd, Aspirin P.O. 0.1 g qd, Atorvastatin P.O. 20 mg qd.	RWM plus Yiqi huayu jiedu decoction P.O. 1/2 dose bid.	6	6	ISR, Response rate of ECG

CHEN K 2014	RWM:	Aspirin, Clopidogrel, Statins, ACEI, Beta blocker, nitrates, CCB.	RWM plus No. 2 Xintong prescription P.O. 200 ml bid.	6	6	ISR

LI B 2014	RWM:	Aspirin, Clopidogrel, Nitrates, Beta blockers, Statins.	RWM plus Qishen yiqi droplets P.O. 0.5 tid.	6	6	ISR, Angina recurrence, Response rate of ECG

LI CW 2014	RWM		RWM plus Qishen yiqi droplets P.O. 0.5 tid.	9	9	ISR
WANG ZQ 2013	RWM:	Aspirin P.O.0.1 g qd, Clopidogrel P.O. 75 mg qd, Atorvastatin P.O. 20 mg qd.	RWM plus Qiwei sanxiong decotion P.O. 150 ml bid.	6	6	ISR, Angina recurrence

ZHANG Q 2013	RWM:	Clopidogrel P.O. 75 mg qd, Aspirin P.O.0.1 g qd, Atorvastatin P.O. 20 mg qd.	RWM plus Shenshao oral lotion P.O. 10 ml tid.	12	12	ISR, MLD, LLL

DENG XD 2013	RWM:	Aspirin P.O.300 mg/d, Clopidogrel P.O. 75 mg/d.	RWM plus Tongxinluo capsule P.O. 4 pills tid	6	6	ISR, MLD

CHEN K 2013	RWM:	Aspirin, Clopidogrel, Statins, ACEI, Beta blockers, Nitrates, CCB.	RWM plus No. 3 Xintong prescription P.O. 100 ml bid.	12	12	ISR

SI XC 2013	RWM		RWM plus Shexiang baoxin wan P.O. 2 pills tid.	6	18	ISR, CD, MI, Angina recurrence, Revascularization

HAN P 2012	RWM:	Aspirin P.O. 300 mg (0–3 m),75–150 mg qd (3–6 m) Clopidogrel P.O. 75 mg qd.	RWM plus combined decoction (Gualou xiebai banxia decoction, Xuefu zhuyu decoction) P.O. 100 ml bid.	6	6	ISR

REN XY 2012	RWM:	Aspirin, Clopidogrel, nitrate, Statins, ACEI.	RWM plus Yiqi huayu decoction P.O. 100 ml bid.	6	6	ISR

NIU XY 2012	RWM		RWM plus Jingqi danshen decoction P.O. 97 g bid.	3	6	ISR Response rate of ECG

GAO XX 2012	RWM:	Aspirin, Clopidogrel, Statins.	RWM plus No. 1 Xintong prescription P.O. 100 ml bid.	6	6	ISR
DAI GF 2011	RWM:	Clopidogrel P.O. 75 mg qd, Aspirin P.O.0.1 g qd, Atorvastatin P.O. 20 mg qd.	RWM plus Tongxinluo capsule P.O.	6	6	ISR, Response rate of ECG

MEI CL 2011	RWM:	Clopidogrel P.O. 75 mg qd, Aspirin P.O.0.1 g qd, Simvastatin P.O. 20 mg qd.	RWM plus Xueyu decoction P.O. 100 ml bid.	3	6	ISR, Angina recurrence

WANG XD 2010	RWM:	Aspirin P.O. 300 mg (0-1m), 100 mg (1–12 m) qd, Clopidogrel P.O. 75 mg qd, Atorvastatin P.O. 20 mg qd.	RWM plus Tongxinluo capsule P.O. 1.14 g tid.	12	12	ISR, Angina recurrence, MI, CD, MLD
WANG XD 2010	Plus placebo P.O. 1.14g tid.		RWM plus Tongxinluo capsule P.O. 1.14 g tid.	12	12	ISR, Angina recurrence, MI, CD, MLD

CHENG SJ 2010	RWM:	Aspirin, Clopidogrel, Glyceryl trinitrate, Metoprolol, Atorvastatin.	RWM plus Anxin granules P.O. 3.5 g tid.	6	6	ISR, MI, PCI

DAI GF 2010	RWM:	Clopidogrel P.O. 75 mg qd, Atorvastatin P.O. 20 mg qd. Aspirin P.O. 100 mg qd,	RWM plus Yiqi huoxue tongmai decoction P.O. 250 ml bid.	12	12	ISR, Response rate of ECG

LIU LL 2010	RWM:	Clopidogrel P.O. 75 mg qd, Atorvastatin P.O. 20 mg qd. Aspirin P.O. 100 mg qd,	RWM plus Jingtian zaitong capsule P.O. 10 g tid.	6	6	ISR, Response rate of ECG

EG = experimental group; CG = control group; RWM = routine western medicine; ECG = electrocardiogram; ACEI = angiotensin-converting enzyme inhibitor; ARB = angiotensin II receptor blockage; CD = cardiac death; MI = myocardial Infarction; MLD = minimum lumen diameter; LLL = late loss of lumen; PCI = percutaneous coronary intervention; CCB = calcium channel blocker.