Review Article

Plants Used as Anticancer Agents in the Ethiopian Traditional Medical Practices: A Systematic Review

Table 5

Families of anticancer MPs with their scientific and local names, habitats, growth forms, parts used, application route and procedures, area of reporting, and forms of cancer treated and distribution in the Ethiopian Flora Region.

FamilyScientific name of the plant Vernacular name¥HabitatPU§ARApplication procedureCancer form describedThe study area reported [Reference]Distribution in the flora region (altitudinal range (m)) [Reference]

AcanthaceaeBarleria eranthemoides R. Br. ex C.B. ClarkeBilinjii (Oro)WSbRtOrDried or fresh root powder with water is given orallyTumorFiche District, Oromia [54]EW, AF, TU, GD, GJ, WU, SU, KF, GG, SD, BA, HA (500-1900) [61]
Hygrophila schulli (Hamilt.) MR. & S.M AlmeidaBala noranti (Oro)WHRtNANANEKERSAAcross the regions of Ethiopia [45]EW, TU, GD, GJ, WU, SU, WG, IL, KF, GG, SD (550-2600) [61]
AloaceaeAloe pirottae Berger (aloe) Iret (Amh)WSbLfOrOne tablespoon of pulp (leaf) is mixed with honey and eaten twice a dayCancerSidama Zone, SNNP Region [62]GG, SD, BA, HA (1300-1820) [63]
AmaranthaceaeCelosia polystachia (Forssk.) C.C. Towns.NAWHLfOr, Ns & DeThe leaf of the plant is applied orally, nasally or topicallyBreast cancerYalo District, Zone 4, Afar Region [64]EW, WU, SU, KF, GG, SD, BA, HA, (300-1300) [65]
AmaryllidaceaeScadoxus multiflorus (Martyn) Raf.Dem astefit (Amh)WHRtDeUsed in combination with other herbs and applied topicallyInternal cancerAcross the regions of Ethiopia [45]EW, GD, SU, AR, WG, KF, IL, GG, SD, BA, HA (1000-3000) [63]
AnacardiaceaeLannea sp. Duduna (Age)WTBrDeTied on the affected partKEMENZINA   NEKERSA/ 
swelling with wound
Across the regions of Ethiopia [45]EW, TU, GD, GJ, WU, SU, AR, WG, KF, GG, SD, BA, ?HA (300-2200) [66]
AnthericaceaeAnthericum angustifolium Hochst. ex A.RichWotet Ashir (Age)WHRtDeCreamed on the surfaceMINSHIRO   NEKERSA/ skin cancerAcross the regions of Ethiopia [45]EW, TU, GD, WU (1300-3000) [63]
Chlorophytum tetraphyllum (L.f) Baker Ye-Eregna kolo (Amh)WHFrOrThe fruit is pounded, cold macerated and drunkNEKERSAAcross the regions of Ethiopia [45]EW, TU, GD, GJ, WU, SU, WG, SD, BA (1250-3400) [63]
ApiaceaeFerula communis L. Doge (Amh)
Etse-Tekhino (Ge’ez)
WHRtOrThe root is crushed and drunk with waterLung cancerLibo Kemkem District, Amhara Region [67]EW, TU, GD, GJ,
WU, SU, SD, BA, HA (1400-3250) [68]
RtNANANEKERSAAcross the regions of Ethiopia [45]
Foeniculum vulgare Mill.Ensilal (Amh)HGHRtOrUsed in combination with other herbs and taken orallyLung cancerAcross the regions of Ethiopia [45]EW, TU, GD, GJ, WU, SU, AR, WG, KF, GG, SD, BA, HA (1600-2350) [68]
ApocynaceaeCarissa spinarum L.Agam (Amh)
Otila (Sid)
WSbFrNANACancerDale District, Sidama Zone, SNNP Region [52]AF, EW, TU, GD, GJ, WU, SU, AR, WG,.KF, GG, SD, BA, HA (550-2500) [68]
Vinca major L.NAHGSbWPNAThe whole areal part is usedCancerLoma and Gena bosa Districts Dawro zone, SNNP Region [59]EW, SU (NA) [68]
AsclepiadaceaeHuernia macrocarpa (A.Rich) SprengerYemidir kulkual (Amh)WHLxInThe latex is mixed with ‘SUMANFAR and inserted in to the cancer woundSkin cancerGubalafto District, North Wello Zone, Amhara Region [69]EW, TU, WU (1600-2400) [68]
Kanahia Laniflora (Forssk.) R. Br.Arust /tifirinde (Amh)WSbLf & LxOr & DeFresh leaf juice with latex is given orally or applied topicallyTumorMecha District, West Gojjam Zone, Amhara Region [42]AF, EW, TU, GD, GJ, SU, AR, IL, KF,
GG, SD, BA, HA, (600-2500) [68]
WPDeNANEKERSAAcross the regions of Ethiopia [45]
AsparagaceaeAsparagus africanus Lam.Yeset kest (Amh)
Serati (Kam)
WSbRtOrNABreast pain/NEKERSAKembatta Tembaro (KT) Zone, SNNP Region [58]EW, TU, GD, GJ, WU, SU, AR, WG, KF, GG, SD, BA, HA (700-3800) [63]
AspleniaceaeAsplenium trichomanes L.Etse-Anbessa (Ge’ez)WSbRtOrNANEKERSAAcross the regions of Ethiopia [45]BA, SU and possibly other regions (2900) [70]
AsteraceaeArtemisia absinthium L.Ariti (Amh)HGHLfOrMixed with Tenadam (Ruta chalepensis), and Zingibil (Zingiber officinale) made into an infusion, filtered and drunkCancerFiche District, North Shewa Zone, Oromia Region [46]EW, TU, GD, SU, WG, HA (1700-2440) [71]
Bidens macroptera (Sch Bip.) ex Chiov. Mesfin Adey Abeba (Amh)WHFlOrPowdered flower part is usedBrain cancerLibo Kemkem District, Amhara Region [67]EW, TU, GD, GJ, WU, SU, AR, IL, KF, GG, BA, HA (1750-3600) [71]
Plectocephalus varians (A. Rich) Jeffrey ex Cufod.Este-Yohannes (Amh)WHWPNAWhole fresh plant is squeezed and appliedTumorMecha District, West Gojjam Zone, Amhara Region [42]EW, TU, GD, GJ, SU, AR, WG, KF, GG, SD, BA, HA (1900-3600) [71]
Vernonia amygdalina Del.Grawa (Amh) Hecho (Sid)WSbShOrTender shoots are pounded and the juice squeezed from the pulp is drunkCancer (as chemoprevention)Sidama Zone, SNNP Region [62]EW TU, WU, GD GJ, SU, WG, IL, KF, GG, SD, BA, HA (650-3000) [71]
Vernonia hymenolepis A. Rich.Qilxuu (Oro)WSbLfNANATumorJimma Zone and Bale Zone, Oromia Region [47, 48]GJ, SU, AR, WG, IL, KF, GG, SD, BA, HA (1200-3000) [71]
Vernonia leopoldi (Sch. Bip. ex Walp.) Vatke (bitter leaf)Merara kitel (Amh)WSbLfNANATumorJimma Zone and Bale Zone, Oromia; Zegie Peninsula, Northwestern Ethiopia, Amhara Region [44, 47, 48]TU, GD, GJ, WU, SU, WG, KF, HA, GG (1850-2850) [71]
BalanitaceaeBalanites aegyptiaca (L.) Del.NAWTLfOr, Ns & DeNABreast cancerYalo District, Zone 4, Afar Region [64]EW, TU, WU, SU, AR, HA, IL, GG, SD (700-1800) [66]
Balanites rotundifolia (van Tieghem) BlatterNAWSbLfOR & DeNABreast cancerYalo District, Zone 4, Afar Region [64]AF, GG, SD (300-1500) [66]
BerberidaceaeBerberis holstii Engl. GB Yeset af / Zinkila (Amh)WSbBrDeBark of the root; used in combination with other herbs and applied topicallyFISTULA  NEKERSAAcross the regions of Ethiopia [45]EW, TU, WU, SU (2406-3200) [65]
BoraginaceaeCordia africana Lam.Wanza (Amh)W/HGTBrDeThe bark of Cordia africana with the root of Plumbago zeylanica is powdered, mixed with butter and creamed on the affected part until recoveryTumors
(‘NEKERSE’)
Debark District, North Gondar Zone, Amhara Region [72]EW, TU, GD, GJ, WU, SU, AR, WG, IL, KF, GG, SD, BA, HA (700-2550) [61]
BrNANACancerDale District, Sidama Zone, SNNP Region [52]
Ehretia cymosa Thonn.Mukerba (Amh)W/HGSbBrBark of the root is used in combination with other herbs and applied topicallyFISTULA  NEKERSA’/ 
rectal & anal cancer
Across the regions of Ethiopia [45]EW, TU, GJ, WU, SU, AR, WG, IL, KF, GG, SD, BA, HA (900-2350) [61]
BrassicaceaeBrassica carinata A. Br.Gomen zer (Amh)HGHSdDeThe seed of B. carinata with seed and leaf of Tarenna graveolens (galo – Amh) is crushed, powdered, mixed with honey and creamed on the affected partSkin cancerDebark District, North Gondar Zone, Amhara Region [72] EW, GD, SU, IL, HA (1350-3850) [65]
CapparidaceaeCadaba farinosa Forssk.Qalaanqaal (Som)WSbLfOrNABreast cancerYalo District, Zone 4, Afar Region[64] AF, EW, TU, GD, GJ, WU, SU, AR, WG, IL, KF, GG, SD, BA (sea level to 2000) [65]
CaryophyllaceaeSilene macrosolen A. RichNAWHLfOrNABreast cancerYalo District, Zone 4, Afar Region [64]TU, GD, WU, SU, AR SD BA, HA (1900-3600 ) [65]
CelastraceaeMaytenus senegalensis (Lam.) ExellAtat (Amh)WSbLfDeIt is pasted on the affected areaCancerGondar Zuria District, Amhara Region [73]EW, TU, WU, GD, GJ, WG, SU, HA, AR, BA, IL, KF, GG, SD (380-2440) [66]
CombretaceaeCombretum Collinum Fresen. Abalo (Amh)WTLfDeThe leaves of Combretum Collinum are pounded, powdered and applied on wound or tumorWound and
Tumors (‘NEKERSA)
Debark District, North Gondar Zone, Amhara Region [72]GJ, SU, (Gibe Gorge),WG, IL, KF, GG, SD, BA, HA (450-1950) [74]
CucurbitaceaeLagenaria siceraria (Molina) StandlBasu baaqula (Sid) HG HLfDeThe leaves are crushed,
squeezed, and applied on the wound
‘NEKERSADega Damot District, Amhara Region [50]GD, GJ, TU, SU, AR, IL, KF, GG, BA, HA (300-2800) [74]
RtOrDry root is pounded, powdered and drunk orallyCancerHawassa city, Sidama Zone, SNNP Region [56]
Momordica friesiorum (Harms) C. JeffreyWof tech (Amh)WHRtDeUsed in combination with other herbs and applied topicallyKAYSI  NEKERSA/ 
invasive cancer
Across the regions of Ethiopia [45]SU, AR, GG, BA, HA (1180-2800) [74]
Zehneria scabra (L.F. Sond) Areg resa (Amh)
Etse-Sabek (Ge’ez)
WHLf & RtNANA‘NEKERSAAcross the regions of Ethiopia [45]EW, TU, GD, GJ, WU, SU, AR, WG, IL KF GG, SD, BA, HA (1200-3580) [74]
EuphorbiaceaeAcalypha fruticosa ForsskNAWSbLfOr, Ns & DeCrushed and applied oral, nasal or topicalBreast cancerYalo District, Zone 4, Afar Region [64]EW, WU, SU, GG, SD, HA (435-1800) [74]
Bridelia micrantha (Hochst.) Baill. Yenebir tifir (Amh)WSbRtNANA‘NEKERSAAcross the regions of Ethiopia [45]GD, GJ, SU, AR, WG, IL, KF, GG, SD, BA (1050-2200) [74]
Clutia abyssinica Jaub. and Spach.Fiyele-fej (Amh)
Este-mefrih (Ge’ez)
WHWPDeThe whole part often together with C. richardiana and C. robusta; used topically‘NEKERSAAcross the regions of Ethiopia [45]TU, GD, WU, GJ, SU, AR, KF, SD, BA, HA (1450-2950) [74]
Croton macrostachyus Del.Bisana (Amh)
Masina (Sid)
WSbLfDeDry/fresh leaves are pounded, powdered and put on the affected partWound cancerWondo Genet District, Sidama Zone, SNNP Region [51]
LfInFresh leaves are crushed and inserted into the woundSkin cancerHawassa city, Sidama Zone, SNNP Region [37]EW, TU, GD, GJ, WU, SU, AR, WG, IL, KF, SD BA HA (500-2350) [74]
LfNANACancerDale District, Sidama Zone, SNNP Region [52]
Euphorbia ampliphylla Pax. Qulquale (Amh)WTFlDeThe flower of Euphorbia ampliphylla is pounded, powdered and mixed with honey and creamed on the affected partSkin cancer (‘LEMTSE)Debark District, North Gondar Zone, Amhara Region [72]TU, GD, GJ, WU, SU, IL, KF, SD, HA (1200-2700) [74]
Rt & LxNARoot and latex of Euphorbia abyssinica, together with Euphorbia caandelabrum & Kotschy and Euphorbit oboalifolia ‘NEKERSAAcross the regions of Ethiopia [45]
Euphorbia dalettiensis M Gilbert. Kelekol (Amh)WSbRt & LxNANAInvasive ‘NEKERSAAcross the regions of Ethiopia [45]HA (1200) [74]
Euphorbia lathyris L.Hadaamii (Oro)HGHStDeStem of Euphorbia lathris is chopped and fumigated to ulcerated breast due to cancerBreast ulcerChelya District, West Shewa, Oromia Region [75]SU, HA (c 2000) [74]
Euphorbia platyphyllos L.Anitrfa (Amh)WHLxDeFresh latex is applied on the tumor topicallyTumorMecha District, West Gojjam Zone, Amhara Region [42]GJ, SU, AR (2000-3200) [74]
Euphorbia polyacantha Boiss.Carricho (Sid)WSbLxDeIts latex is squeezed and creamed on the affected areaSkin cancer (tumor)Delanta District, Northwestern Wello, Amhara Region [60]EE, EW, TU, WU, SU, BA, HA (1200-2250) [74]
Euphorbia tirucalli L. Kinchib (Amh) Shuraamo carre (Sid)WTLxDeLatex dropped on the affected partSkin cancerWondo Genet District, Sidama Zone, SNNP Region [51]EW, TU, WU, SU, IL, GG, SD, BA, HA (1300-2000) [74]
NANANAUnidentified swellings/ Neck CancerDebre Libanos monastery, North Shewa Zone, Oromia Region [53]
Phyllanthus ovalifolius Forssk.Sosiye (Amh)WSbRtNANA‘NEKERSAAcross the regions of Ethiopia [45]GD, GJ, WU, WG SU, AR, IL, KF, GG, SD, BA, HA (900-2750) [74]
Ricinus communis L. Gulo (Amh) Qonbo”o (Sid)HGHRtOrFresh root is chewed and swallowedBreast cancerHawassa city, Sidama Zone, SNNP Region [55, 56]TU, GD, WU, SU,
WG, IL, KF, GG, SD, BA, HA (400-
2500) [74]
LxNANA‘NEKERSAAcross the regions of Ethiopia [45]
FabaceaeAcacia oerfota (Forssk.) Schweinf.Seraw (Tig)WSbLfNs & DeCrushed and applied nasally and/or topicallyBreast cancerYalo District, Zone 4, Afar Region [64]AF, EW, TU, WU, SU, BA, HA, SD (100-1600) [66]
Acacia tortilis (Forssk.) Hayne.Seraw (Tig)WTLfNs & De Crushed and applied nasally and/or topicallyBreast cancerYalo District, Zone 4, Afar Region [64]AF, EW, TU, WU, SU, AR, HA, BA (600-1900) [66]
Calpurnia aurea (Alt.) Benth. Digita (Amh)WSbLfOrThe powdered leaf of the plant is mixed with root of Cucumis ficifolius (Yemidir Embuay) is cold macerated and given orallyUnidentified
swellings/ Cancer
Debre Libanos monastery, North Shewa Zone, Oromia Region [53]EW, TU, GD, WU, GJ, WG, SU, AR, BA, HA, KF, GG, SD (1650-3000) [66]
Colutea abyssinica Kunth & BouchéDuaduate (Amh)WSbRt & SdDeUsed in combination with other herbs and applied topicallyCervical and rectal cancerAcross the regions of Ethiopia [45]EW, TU, GD, WU, SU, AR, BA, HA, SD (1600-4000) [66]
Dichrostachys cinerea (L.) Wight et Am.Ader (Amh)WSbRtOrRoot of the plant is crushed and taken orallySkin bleaching (cancer)Yalo District, Zone 4, Afar Region [64]EW, TU, WU, GJ, WG, SU, AR, BA, HA, KF, GG, SD (450-2000) [66]
Erythrina brucei Schweinf.Kuara /Korch (Amh)
Welekko (Sid)
WTBrNANACancerDale District, Sidama Zone, SNNP region [52]WU, WG, GJ, SU, BA, HA, IL, KF, GD, GG, SD (1400-2600) [66]
Indigofera oblongifolia Forsk.NAWSbLfOr & DeLeaf of the plant is used orally and as a body washBreast cancerGubalafto District, North Wello Zone, Amhara Region [69]AF, EW, HA, BA, KF, GG, SD (up to 1200) [66]
Millettia ferruginea (Hochst.) BakerBirbira (Amh)
Hengedicho (Sid)
WTBrOrNA/ The bark is washed, pounded, filtered and given orallyCancerDale District, Sidama Zone, SNNP region [52]WG, SU, HA, BA, IL, KF, SD (1600-
2500) [66]
Senna alexandrina Mill.Mekerbaa (Oro)WSbBrDeThe bark is pounded and creamed on the swellingNEKERSAAcross the regions of Ethiopia [45]AF, EW (0-1400) [66]
Senna italica Mill.NAWHLfOr & DeLeaf of the plant is used orally and as a body washBreast cancerYalo District, Zone 4, Afar Region [64]AF, EW, TU, GD (0-1850) [66]
Senna septemtrionalis (Viv.) Irwin & BarnebyNAWHLfOrThe Leaf is crushed in water and the filtrate is drunkLung cancerGubalafto District, North Wello Zone, Amhara Region [69]SU, AR, HA, IL, KF, SD (1700-2400) [66]
Senna singueana (Del.) LockKey enchet (Amh)
Busha (Age)
WSbLf & BrDeApplied topically‘MINSHIRO  NEKERSAAcross the regions of Ethiopia [45]EW, TU, GD, WU, GJ, SU, SD (1500-2400) [66]
Sesbania sesban L.Merr. Bofefe – AmhWSbRtNANA‘NEKERSAAcross the regions of Ethiopia [45]AF, EW, TU, GD (Sudan border), WU, GJ, WG, SU, AR, HA, IL, KF, GG, SD (300-2000) [66]
FlacourtiaceaeDovyalis abyssinic a (A. Rich.) Warb Koshim (Amh)WSbFrOrSix to ten fruits are eatenCancerFiche District, Oromia [54]
BrOrThe raw bark of Dovyalis abyssinica is chewed and swallowed ‘MUJE /Lymphatic tumorDale District, Sidama Zone, SNNP Region [55]TU, GD, GJ, WU, SU, AR, GG, SD, BA, HA (1700-3000) [65]
WPDeCreamed on the affected part‘NEKERSAAcross the regions of Ethiopia [45]
IridaceaeGladiolus candidus (Rendle), Goldblatt Milas Golgul (Amh) Hanxxaye (Oro)WHRtOr & DeThe root is powdered and applied on the wound, or the powder is mixed with water and drunk‘NEKERSA(cancer)Across the regions of Ethiopia; Dega Damot District, Amhara Region [45, 50]AR, SD, BA, HA (1450-2250) [63]
JuncaceaeJuncus effusus L.Etse felatsut (Amh)WHRtDeUsed in combination with other herbs and applied topicallyKAYSI  NEKERSAAcross the regions of Ethiopia [45]AR, BA (2400-3120) [63]
LamiaceaeAjuga integrifolia Buch.-Ham. ex D. DonEtse-libawit (Ge’ez)
Harma guusaa (Oro)
WHbLfDeApplied on affected breastBreast cancer massageJimma Zone, Oromia Region [47]EW, TU, GD, GJ, WU, SU, KF, SD, BA, HA (1500-3400) [61]
Clerodendrum myricoides (Hochst.) VatkeMisrichi (Amh)
Mardhisiisaa (Oro)
Ma’niisa (Sid)
WHLfOrThe leaf part will be pounded, mixed with honey and drunk; or its root boiled often mixed with the shoot of Zanthoxylum chalybeum Cancer (Leukemia)Dale District, Sidama Zone, SNNP Region [55]TU, GD, WU, SU,
AR, WG, IL, KF, GG, SD, HA (700-
2600) [61]
Leonotis ocymifolia (Burm.f.) IwarssonYe feres zeng (Amh)WSbLfDeChopped leaves are applied to the ulcer for 24 hoursUlcer of the neck (‘NEKERSA)Fiche District, North Shewa Zone, Oromia Region [46]EW, TU, GD, WU, GJ, SU, AR, WG, IL, KF, GG, SD, SA, HA (500-3700) [61]
Leonotis raineriana De FC (Vis.)Ras kimir (Amh)WSbRtNAOften used with Leonotis Africana and an application is not givenMINSHIRO  NEKERSAAcross the regions of Ethiopia [45]EW, TU, GD, WU, GJ, SU, AR, WG, IL, KF, GG, SD, SA, HA (500-3700) [61]
Salvia nilotica Jacq.Hulegeb (Amh)WHRtNANA‘NEKERSAAcross the regions of Ethiopia [45]All Flora region, except AF (1300-3800) [61]
Satureja abyssinica (Benth.) Briq.Este meaza (Amh)WSbLfDeUsed in combination with other herbs and applied topicallyInternal cancerAcross the regions of Ethiopia [45]EW, TU, GD, GJ, WU, SU, AR, KF, GG, SD, BA, HA (900–2700) [61]
LinaceaeLinum usitatissimum L.Telba (Amh)HGHSdOrNABreast pain/NEKERSAKembatta Tembaro (KT) Zone, SNNP Region [58]Throughout the highlands (1600-3800) [65]
LobeliaceaeLobelia giberroa Hemsl.Jibira (Amh)WTLxNANA‘NEKERSAAcross the regions of Ethiopia [45]EW, TU, GD, SU,
WG, IL, KF, GG, SD, HA, BA (1700-2800) [61]
Lobelia rhynchopetalum Hemsl.Etse-kemun (Ge’ez)WTRtDeUsed in combination with other herbs andapplied topicallyMINSHIRO  NEKERSAAcross the regions of Ethiopia [45]GD, GJ, SU, AR, BA, HA (3000-4350) [61]
LoganiaceaeBuddleja polystachya Fresen Anfar (Amh)
WSbLfOrPounded, cold macerated and taken orallyCancerDale District, Sidama Zone, SNNP Region [55]AF, TU, GD, GJ,
WU, SU, AR, WG,
KF, SD, BA, HA (700-3300) [68]
.Bullaancho (Sid)LfNANAMINSHIRO  NEKERSAAcross the regions of Ethiopia [45]
MalvaceaeMalva verticillata L. Lut (Amh)WHLfDeThe leaf is crushed, warmed on fire and tied on the swellingSwelling by ‘NEKERSAAda’a District, East Shewa Zone Oromia Region [31] EW, TU, GD, GJ, WU, SU, AR
WG, KF, SD, BA, HA (l600-4000) [74]
NANANAUnidentified swellings/ Neck CancerDebre Libanos monastery, North Shewa Zone, Oromia Region [53]
Sida schimperiana Hochst. ex. A. Rich.Chefreg (Amh)WSbLf & RtDeThe leaf and root of Sida schimperi is pounded,
powdered and then applied on
affected part
Wound and
Tumors
(NEKERSA)
Debark District, North Gondar Zone, Amhara Region [72]EW, TU, GD, GJ, SU, WG, SD, BA HA (1500-2600) [74]
RtOrThe juice of freshly squeezed root is mixed with honeyBreast cancerNekemte Town, East Wellega, Oromia Region [76]
MeliaceaeEkebergia capensis Sparm Duduna (Amh)
Simboo (Oro) Goddiicho (Sid)
WSbRt & BrNANA‘NEKERSAAcross the regions of Ethiopia [45] TU, WU, GD, GJ,
WG, SU, AR, IL, KF, SD, BA, HA (1680-3000) [66]
FrOrThe fruit of the plant is pounded, filtered and drunkCancerDale District, Sidama Zone, SNNP Region [55]
MelianthaceaeBersama abyssinica Fresen.Azamir (Amh) Xeweerrakko (Sid)WTBrOrThe bark of the plant pounded boiled and a small amount of the preparation is drunkCancerDale District, Sidama Zone, SNNP Region [55]TU, GD, WU, WG,
GJ, SU, IL, KF, AR, HA, BA, SD (1700-2715) [66]
MenispermaceaeStephania abyssinica (Dillon & A. Rich.) Walp. Engochit (Amh)
Etse Eyesus (Ge’ez) Kalaala (Sid)
WHLfDeFresh leaves are rubbed by hand and droplets are applied on the skinSkin cancerWondo Genet District, Sidama Zone, SNNP Region [51]EW, TU, GD, GJ, WU, SU, AR, WG, KF, IL, GG, SD, HA (1450-3400) [65]
MoraceaeDorstenia barnimiana Schwienf. Work Bemeda (Amh)WHRtInSmall opening is made in the affected area and the root is insertedCancerZegie Peninsula, Northwestern Ethiopia, Amhara Region [44]GD, SU, HA, SD, BA, IL, GG (500-2450) [66]
Ficus palmata Forssk.Beles (Amh)WSbLf & RtDeIts root and leaves with bulb of Allium sativium, fruits of Lagenaria siceraria crushed together, backed with powder of teff and then applied on woundsSkin cancer (‘LEMTSE)Minjar-Shenkora District, North Shewa Zone, Amhara Region [77]EW, TU, GD, GJ, WU, SU, HA, AR, KF (1000-2400 ) [66]
BrNANAKAYSI  NEKERSAAcross the regions of Ethiopia [45]
Ficus sur Forssk. Shola (Amh)WTRt, Br & FrNANAKEMENZINA  NEKERSAAcross the regions of Ethiopia [45]EW, TU,WU, GD, GJ, WG, SU, HA, AR, IL, KF, SD (1400-2500) [66]
MyrsinaceaeMyrsine africana L. Quechemo (Amh)WSbFrOrDried fruit with dried leaf of Osyris quadripartita, powdered, mixed with little water is given orallyCancerFiche District, North Shewa Zone, Oromia Region [54]EW, TU, GD, GJ, WU, SU, AR, KF, SD, BA, HA (1900-3800) [68]
Myrsine Melanophloeos
(L.) R. Br.
Morocho (Sid)WTLfOrThe leaf (often mixed with Olea capensis) is pounded, cold macerated and drunkCancer (leukemia)Dale District, Sidama Zone, SNNP Region [55]TU, GD, GJ, SU, AR, WG, GG, BA (2500-3750) [68]
OleaceaeOlea capensis L.f.Seettaame (Sid)WTShOrThe shoot part is boiled, mixed with honey and drunk; Shoot of Zanthoxylum chalybeum and Clerodendrum myricoides are often boiled togetherCancerDale District, Sidama Zone, SNNP Region [55]GD, SU, AR, IL, KF, SD, BA (1350-
3200) [68]
Olea europaea subsp.
Cuspidate (Wall. ex. G. Don) Cif.
Woira (Amh)WTFrNsThe dried fruit and Embelia schimperi fruit powder with water is given nasally before foodTumorMecha District, West Gojjam Zone, Amhara Region [42]AF, EW, TU, GD, WU, SU, KF, GG,
SD, BA, HA, (1250-3000) [68]
PhytolaccaceaePhytolacca dodecandra L 'Herit.Endod (Amh)WSbLf & RtNARoot and leaf of the plant is used by chopping and pounding;Cancer/swelling of glandLoma and Gena bosa Districts Dawro zone, SNNP region [59]EW, TU, BA,GG, GD, WU, GJ, WG, SU, IL, KF, AR, SD, HA (1500-3000 ) [65]
PittosporaceaePittosporum abyssinicum Del.Lola (Amh)
Boncho (Sid)
WSbBrNANACancerDale District, Sidama Zone, SNNP region [52]GD, SU, BA, HA (2300-3200) [66]
PlantaginaceaePlantago lanceolata L.Qorxobi (Oro)WHSdDeDried seeds are crushed, powdered and applied to the cancer woundCancerHawassa city, Sidama Zone, SNNP Region [56]EW, TU,GD, GJ, WU, SU, WG, IL, KF, GG, SD, BA (1200-3200) [61]
PlumbaginaceaePlumbago zeylanica L.Amera (Amh)
Aftuh (Tig)
Mexres (Som)
WHLfOrLeaf of P. zeylanica is squeezed and the juice is taken orallyCancerGhimbi District, West Wollega Zone, Oromia Region [43]
RtDeRoot powder mixed with “digne” (sulfur) is applied/ dressed with root pasteCancerZegie Peninsula, Northwestern Ethiopia, Amhara Region [44]
ShOrFresh shoot boiled with water is given orallyStomach tumorMecha District, West Gojjam Zone, Amhara Region [42]AF, EW, TU, GD
GJ, WU, SU, AR, IL, GG, SD, BA, HA (700-2200) [61]
RtNANAKAYSI  NEKERSAAcross the regions of Ethiopia [45]
RtOr & DeThe root part is boiled and consumed orally and also applied topicallyBone cancerJeldesa Cluster, Dire Dawa city Administration [41]
PodocarpaceaeAfrocarpus falcatus (Thunb.) C.N.PageZigba (Amh)WTLfNANACancerDale District, Sidama Zone, SNNP region [52]TU, GD, GJ, WU, SU, AR, IL, KF, GG, WG, SD, BA, HA (1350-2900) [78]
PolygonaceaeOxygonum sinuatum (Meisn.) DammerKurnchit (Amh)WHWPDeWhole part is creamed on the affected partNEKERSAAcross the regions of Ethiopia [45]EW, TU, GD, GJ,
SU, GG, SD, BA, HA (600-2500) [65]
Rumex abyssinicus Jacq.Mekmeko (Amh)
Este-berhan (Ge’ez)
Shiishoone (Sid)
HGHRtDeThe root is pounded and creamed on the swellingNEKERSAAcross the regions of Ethiopia [45]EW, TU, GD, GJ, SU, AR, WG, KF, IL, GG, SD, BA, HA (1200-3300) [65]
RtOrRoot powder is mixed in spicy stew to increase its power of curing and taken orallyCancerSeharti Samre District, Southern Tigray Region [57]
Rumex nervosus Vahl.Huhot/Embuacho (Amh) Dhangaggoo (Oro)WSbLfDeLeaves are crushed and pasted on the affected areaBreast cancerSeharti Samre District, Southern Tigray Region [57]EW, TU, GD,, GJ, WU, SU, AR, GG, SD, HA (400-3300) [65]
PunicaceaePunica granatum L.Roman (Amh)HGSbFrOrThe fruit is crushed and eatenCancerLibo Kemkem District, Amhara Region [67]EW, SU, KF, and probably elsewhere (1000-2450) [65]
RanunculaceaeClematis bracteata (Roxb.) KurzYeazo Areg (Amh)WClWPDeThe plant is crushed and mixed with butter and appliedCancerBale area, Southeast Ethiopia, Oromia Region [79]GD, GD/GJ, GJ, SU, WG, KF, IL, SD (1350-3300 ) [65]
Clematis hirsuta var. hirsuta./Perr. and Guill. Nech yeazo Areg (Amh)
WClLf, St & BrOrLeafs/stem and bark are mixed with leafs of Plectranthus ingiarius then pounded, filtered and drunkBreast cancerWondo Genet District, Sidama Zone, SNNP Region [51]
LfDeThe leaves are crushed and applied on the swelling as bandageSwelling by NEKERSADega Damot District, Amhara Region [50]EW, TU, GD, GJ, WU, SU, AR, IL, KF, SD, BA, HA (850- 3200) [65]
LfOr & InThe leaves are pounded to make a solution and half of small glass is drunk; certain amount of the solution is applied into the hole of the wound using syringe or other domestic material; the residue is put on the opening of the wound.Bone cancerBlue Hora District, Borana Zone, Oromia Region [49]
Clematis simensis Fresen.Fiide (Sid)WClLfDeThe leaves are crushed, powdered and then creamedCancerLibo Kemkem District, Amhara Region [67]GD, TU, WU, GJ,
SU, AR, WG, KF,
GG, SD, BA, HA
(1500-3350) [65]
LfOrLeaves of the plant will be macerated and drunkCancerDale District, Sidama Zone, SNNP Region [55]
Ranunculus multifidus Forssk. Etse Siol (Amh/Ge’ez)WHLfDeThe leaf is powdered and dressed externallyNEKERSA (Cancer)Debre Libanos monastery, North Shewa Zone, Oromia Region [53]EW, TU, GD, GJ, WU, SU, AR, WG, IL, KF, SD, BA, HA (1200-3800)[65]
Thalictrum rhynchocarpum Dill. & A. Rich.Sire bizu (Amh)WHRtDeUsed in combination with other herbs and applied topically‘KEMENZINA  'NEKERSAAcross the regions of Ethiopia [45]TU, GD, GJ, SU, AR, WG, IL, KF, HA (1600-3050) [65]
RhamnaceaeZiziphus mauritiana Lam.NAWSbLfOrNABreast cancerYalo District, Zone 4, Afar Region [64]IL, GG, SD, SD-BA, HA (400-1600) [66]
Ziziphus spina-christi L. Desf. Geba (Amh/Age) Qurqura (Oro)WTRt & FrNANAMINSHIRO  NEKERSA; TumorsAcross the regions of Ethiopia [45, 80]AF, EW, TU, GD, WU, SU, GG, BA, HA (0-2400) [66]
RosaceaeHagenia abyssinica (Bruce) J.F.Gmel. Kosso (Amh)WTRtDeThe root is pounded and mixed with honey, then creamed on the affected partMINSHIRO  NEKERSAAcross the regions of Ethiopia [45]EW, TU, GD, WU, GJ, WG, SU, AR, BA, HA, KF, SD (2450-3250) [66]
Prunus Africana (Hook. f.) KalkmTikur Enchet (Amh)WTBrOrLiquid extracts from P. Africana bark is pounded, juiced and taken orallyBenign prostatic hyperplasia,
prostate gland hypertrophy
Ghimbi District, West Wollega Zone, Oromia Region [43]GD, GJ, WG, SU, AR, BA, HA, IL, KF, SD (1700-2500) [66]
Rosa abyssinica LindleyKega (Amh)WSbRt & FlNANA‘NEKERSAAcross the regions of Ethiopia [45]EW, TU, GD, WU, GJ, SU, AR, HA, BA (1900-3300) [66]
RubiaceaeRubia cordifolia L.Enchibir (Amh)WHRtDeUsed in combination with other herbs and applied topicallyInternal cancerAcross the regions of Ethiopia [45]EW, TU, GD, GJ, WU, SU, AR, KF, SD, BA, HA, (1000-2850) [68]
RtOrThe root part is crushed in water for 3 days and taken orallyLung cancerGubalafto District, North Wello Zone, Amhara Region [69]
RutaceaeFagaropsis angolensis (Engl.) DaleOloncho (Sid)WSbFrNANACancerDale District, Sidama Zone, SNNP region [52]TU, WU, GD, GJ,
WG, SU, AR, IL, KF, SD, BA, HA (1680-3000) [66]
Zanthoxylum Gadda (Sid/O ro)WTLfOrThe leaves are dried, powdered, cold macerated and drunkBreast cancerHawassa city and Dalle District, Sidama Zone, SNNP Region [52, 55, 56]GG, BA, HA (900-
1550) [66]
chalybeum Engl.RtNANACancer
SantalaceaeOsyris quadripartita Decn. Queret (Amh)WTLfOrDried leaf with dried fruit of Myrsine africana, is powdered, mixed with water and given orallyCancerFiche District, Oromia Region [54]EW, TU, GD, WU,
GJ, WG, SU, KF, GG, AR, HA, BA, SD (1600-2900) [66]
SapindaceaeDodonaea angustirolia L. f. Kitkita (Amh) Ittancha (Sid)WSbLfNANACancerDale District, Sidama Zone, SNNP Region; Across the regions of Ethiopia [45, 52]EW, TU, GD, WU, SU, AR, GJ, WG, KF, GG, SD, BA, HA (500-2900) [66]
NANANAUnidentified swellings/ Neck CancerDebre Libanos monastery, North Shewa Zone, Oromia Region [53]
SapotaceaeSideroxylon oxyacanthum Baill.Bunguude (Sid)WSbLfOrThe leaf part macerated and taken orallyCancerDale District, Sidama Zone, SNNP Region [55]TU, GD, SU,
AR, BA, HA (1250-2800) [68]
ScrophulariaceaeCraterostigma pumilum Hochst.Delashut (Amh)WHLf & FlDeUsed in combination with other herbs and applied topicallyCervical and rectal cancerAcross the regions of Ethiopia [45]GD, EW, SU, HA, BA, WU, GJ, TU (1300-3100) [61]
Rhamphicarpa fistulosa (Hochst.) Benth.Yeset lib (Amh)WHFlOrUsed in combination with other herbs and given orallyLung cancerAcross the regions of Ethiopia [45]GD, GJ, WG, KF (800-1650) [61]
SimaroubaceaeBrucea antidysenterica J.F. Mill. Yedega Abalo (Amh)WSbSt & BrOrDecoction is drunkCancerJimma Zone and Bale Zone, Oromia Region [47, 48]EW, TU, GD, GJ, WG, SU, AR, IL,
KF, SD, BA, HA (1650-2800) [66]
Waginos (Ge’ez)LfDeThe leaves are collected and dried, the powder is then applied to the skinCancerFiche District, North Shewa Zone, Oromia Region [46]
SolanaceaeNicotiana tabacum L.Timbaho (Amh)HGHLfDeThe leaf is pounded and creamed on the swellingNEKERSAAcross the regions of Ethiopia [45]EW, TU,GD, SU, WG, KF, GG, SD, HA (300-2400) [61]
Solanum gigantum Jacq. Tikur Embuay (Amh)
Ziza (Kam)
WSbLfDeNABreast painKembatta Tembaro (KT) Zone, SNNP Region [58]GD, GJ, WG, IL, KF, SD, BA (1100-2300) [61]
Withania somnifera (L.) Dunal in DC.Gizawa (Ama)WSbNANANACancerFiche District, North Shewa Zone, Oromia Region [46]AF, EW, TU,GD, GJ, WU, SU, KF, GG, SD, HA (600-2700) [61]
VitaceaeCyphostemma adenocaule (Steud. ex. A. Rich.) Descoings exWild & DrummondAsserkush (Amh)WClLfDeThe leaf part is warmed up and pasted on the affected areaSwelling by NEKERSAAda’a District, East Shewa Zone Oromia Region; Across the regions of Ethiopia [31, 45]EW, TU, GD, GD-GJ, WU, SU, WG, IL, KF, GG, SD, BA, HA (600-2650) [66]
Cyphostemma cyphopetalum (Fresen.) Descoings ex Wild&Drummond Gindosh (Amh) Kelkalo (Oro)WClRt & FlNANANEKERSAAcross the regions of Ethiopia [45]AF, EW, TU, GD, WU, SU, SU-AR, GJ, WG, GG, SD, BA, HA (250-2800) [66]
ZygophyllaceaeTribulus terrestris L.Ch’amare (Oro)WHFrNANACancerAcross the regions of Ethiopia [80]EW, WU, SU, AR, SD, HA (sea level up to 2300) [65]

Note: PU§= part used (Lf-leaf; Rt=root; Br=bark; Fl; flower; Fr=fruit; Sd=seed; Lx=latex; Sh=shoot; St=stem; WP=whole part); AR=application route (Or=oral; De=dermal; In=insertion; Ns=nasal); = growth forms (T=tree; Sb=shrub; H=herb; Cl=climber/liana); habitat (W=wild; HG=home garden); Key: ¥local names: Ge’ez: Ge’ezinga; Amh: Amharic; Tig: Tigrigna; Oro: Afaan Oromoo; Sid: Sidamu-afoo; Age: Agewugna; Kam: Kambatissa; Som: Somali; NA= not available. Note: vernacular names of malignancies/cancer are written in small caps, Italic, font 10, within single inverted commas throughout the document.
TU: Tigray region above 1000 m contour; AF: Afar region below 1000 m contour to Eritrean border in the east and Harerge border in the south; WU: Welo region above 1000 m contour; GD: Gondar region; WG: Welega region; KF: Kefa region; AR: Arsi region; BA: Bale region; GJ: Gojam region; IL: I1ubabor region; GG: Gamo Gofa region; SD: Sidamo region; HA: Harerge region.