Optimized Extract from Corylopsis coreana Uyeki (Hamamelidaceae) Flos Inhibits Osteoclast Differentiation

Osteoclast differentiation was inhibited by C. coreana Uyeki flos extracts. BMMs were cultured for 4 days in 0.1% DMSO (control vehicle) or the concentration 30 μg/ml of C. coreana Uyeki flos extract with RANKL (10 ng/mL) and M-CSF (30 ng/ml). The inhibitive patterns of osteoclast differentiation based on the alcoholic percentage of extracts (a). The inhibitive patterns of osteoclast differentiation based on the concentration of the 80% alcoholic extract of C. coreana Uyeki flos (b).