Research Article
Development of a HPLC-MS/MS Method to Determine 11 Bioactive Compounds in Tongmai Yangxin Pill and Application to a Pharmacokinetic Study in Rats
Table 1
Mass spectra properties of 11 analytes and IS.
| | Compounds | Precursor Ion (m/z) | Product Ion (m/z) | Frag. (V) | C.E. (V) |
| | rhein | 238.9 | 211.0 | 140 | -10 | | emodin | 269.0 | 225.0 | 145 | -20 | | stilbene glycoside | 405.2 | 242.8 | 145 | -13 | | liquiritin | 417.1 | 255.0 | 145 | -13 | | ononin | 431.2 | 269.1 | 10 | 13 | | verbascoside | 623.0 | 161.1 | 116 | -33 | | gallic acid | 169.0 | 125.1 | 123 | -12 | | schisandrin | 433.3 | 384.2 | 100 | 14 | | liquiritigenin | 255.3 | 119.1 | 121 | -24 | | glycyrrhizic acid | 821.1 | 350.5 | 125 | -40 | | isoliquiritigenin | 255.1 | 118.9 | 106 | -23 | | icariin (IS) | 721.0 | 513.2 | 145 | -10 |
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