Evidence-Based Complementary and Alternative Medicine / 2018 / Article / Tab 4

Research Article

Development of a HPLC-MS/MS Method to Determine 11 Bioactive Compounds in Tongmai Yangxin Pill and Application to a Pharmacokinetic Study in Rats

Table 4

Extraction recoveries and matrix effects of the analytes (n=6).

CompoundsSpiked concentration (ng/mL)Extraction recovery (%)RSD (%)Matrix effect (%)RSD (%)

rhein196.2±7.47.7104.1±5.65.4
1099.3±3.93.9100.1±2.72.7
100101.4±5.25.192.6±3.74.0
emodin298.8±3.43.5107.7±2.62.4
2096.2±2.52.6103.6±0.80.8
20086.1±4.24.9104.8±2.92.8
stilbene glycoside298.9±1.91.9100.7±2.22.2
2099.3±4.04.094.6±2.22.3
20096.7±5.65.898.7±0.80.9
gallic acid299.1±3.13.2110.4±5.85.2
20100.9±2.52.598.3±2.02.0
20085.2±3.03.5108.1±1.31.2
ononin291.8±2.72.998.6±2.82.8
2089.0±3.84.389.9±0.70.8
20093.1±5.25.691.7±0.91.0
verbascoside193.1±4.04.3103.6±3.33.1
1097.0±4.74.8100.0±2.12.1
10092.5±6.16.698.9±2.32.4
liquiritin10105.7±4.54.398.8±1.21.2
100109.1±4.03.6100.1±6.46.4
100099.5±7.67.795.2±5.55.8
schisandrin298.8±4.14.296.8±2.62.7
20106.3±1.11.093.0±1.71.8
200101.0±6.05.990.4±0.70.8
liquiritigenin199.7±3.53.6113.4±2.82.5
1099.5±2.72.789.2±1.31.5
10096.3±3.43.599.8±1.81.8
glycyrrhizic acid20100.9±7.57.4101.6±6.86.7
20097.5±2.12.1102.5±1.31.3
200087.6±1.61.8103.7±2.12.0
isoliquiritigenin198.0±5.55.6105.73±2.22.1
1096.5±2.02.198.0±3.63.6
10085.9±5.76.797.3±3.13.2

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