Research Article

Development of a HPLC-MS/MS Method to Determine 11 Bioactive Compounds in Tongmai Yangxin Pill and Application to a Pharmacokinetic Study in Rats

Table 5

Stability of all analytes in rat plasma (n=6).

CompoundsSpiked Concentration (ng/mL)room temperature for 6 hthree freeze-thaw cyclesauto-sampler for 12 h-70°C for 14 days
Measured Concentration (ng mL−1)RSD (%)Measured Concentration (ng mL−1)RSD (%)Measured Concentration (ng mL−1)RSD (%)Measured Concentration (ng mL−1)RSD (%)

rhein10.97±0.022.00.98±0.032.80.97±0.010.80.95±0.055.4
1010.23±0.040.48.89±0.080.99.86±0.090.98.71±0.111.3
100101.97±1.071.186.7±1.331.597.32±1.051.185.95±0.390.5
emodin21.95±0.052.32.00±0.020.91.93±0.020.81.86±0.031.6
2021.14±0.994.719.21±0.331.719.88±1.819.118.79±0.180.9
200207.49±1.270.6197.74±5.652.9200.50±11.665.8185.45±0.980.5
stilbene glycoside21.82±0.010.82.00±0.031.61.89±0.000.11.99±0.010.3
2020.88±1.195.719.87±1.437.219.00±0.643.420.01±0.311.6
200202.79±12.806.3200.45±2.101.1182.40±1.230.7203.34±1.390.7
gallic acid21.97±0.031.51.93±0.041.82.03±0.052.31.99±0.042.0
2020.77±1.095.320.08±0.512.519.27±0.351.819.26±0.221.2
200205.97±2.141.0196.77±1.090.6184.54±2.461.3199.19±1.800.9
ononin22.02±0.031.41.85±0.010.71.83±0.010.41.95±0.010.5
2020.57±0.261.218.71±0.261.418.84±0.623.318.51±0.150.8
200216.32±0.910.4191.28±2.361.2195.34±4.302.2200.23±3.891.9
verbascoside10.92±0.011.01.09±0.010.91.05±0.021.81.01±0.022.3
109.57±0.212.210.17±0.908.99.50±0.040.59.81±0.222.2
100103.95±1.331.3108.42±1.171.193.52±0.270.3107.40±1.471.4
liquiritin109.85±0.091.09.26±0.161.710.26±0.111.110.04±0.121.2
100108.97±1.511.4109.67±1.861.7108.02±0.660.6105.05±1.731.7
10001076.07±10.271.0952.89±11.221.2869.12±14.521.71021.69±19.982.0
schisandrin22.00±0.041.81.71±0.010.61.83±0.021.11.77±0.031.7
2021.15±0.502.418.28±0.231.218.35±0.090.517.86±0.201.1
200194.61±1.130.6189.32±1.740.9196.02±2.101.1183.83±1.000.6
liquiritigenin10.87±0.010.90.89±0.021.80.87±0.011.10.88±0.022.1
1010.82±0.585.38.99±0.070.88.63±0.232.79.26±0.080.9
100112.69±1.301.292.59±0.630.792.65±0.680.791.88±0.860.9
glycyrrhizic acid2020.49±0.793.919.30±0.201.019.25±0.341.818.77±0.090.5
200203.22±3.321.6188.63±3.571.9200.96±3.932.0200.33±2.981.5
20002099.10±8.920.41869.00±42.552.31884.66±9.260.51834.54±29.341.6
isoliquiritigenin10.99±0.011.50.89±0.022.41.00±0.021.70.89±0.011.4
1010.86±0.605.58.69±0.141.69.60±0.040.48.62±0.040.4
100106.11±0.780.7100.58±0.910.997.47±1.992.0100.74±2.952.9