Absorption Characteristics of Combination Medication of Realgar and Indigo Naturalis: In Vitro Transport across MDCK-MDR1 Cells and In Vivo Pharmacokinetics in Mice after Oral Administration

Figure 4

Effects of realgar (R), indigo naturalis (I), and realgar and indigo naturalis (RI) on K562 cell viability. (a) The cell viability of K562 after treatment with various concentrations of R (0, 3.5, 7, 14, and 28 μg/mL) for 24 h. (b) The cell viability of K562 after treatment with various concentrations of I (0, 7, 14, 28, and 56 μg/mL) for 24 h. (c) The cell viability of K562 after treatment with various concentrations of RI (0, 3.5, 7, 14, and 28 μg/mL of R and 0, 7, 14, 28, and 56 μg/mL of I) for 24 h. Data are represented as the mean ± SD from three independent experiments (p < 0.05 versus control).

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