Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLC/QQQ-MS/MS

Table 8

Effect of P. ginseng on the pharmacokinetics of mesaconitine at day 7 after administration.

Mesaconitine	Control	P. ginseng-low	P. ginseng-middle	P. ginseng-high
(μg/Lh)	51.24 ± 21.48	65.53 ± 9.06	82.45 ± 18.57	126.07 ± 44.93
(μg/Lh)	58.66 ± 27.59	71.36 ± 12.85	87.1 ± 21.80	138.96 ± 55.36
(h)	13.17 ± 10.45	12.12 ± 6.11	10.31 ± 3.00	12.56 ± 4.48
(h)	1.58 ± 1.32	0.89 ± 0.60	1.83 ± 1.21	2.20 ± 1.98
/F (L/kg)	3146.87 ± 1886.84	2386.47 ± 832.39	1745.91 ± 488.37	1395.19 ± 472.75
/F (L/h/Kg)	217.47 ± 130.54	144.13 ± 26.77	120.75 ± 29.09	81.37 ± 29.62
(μg/L)	5.48 ± 2.61	4.66 ± 1.03	6.02 ± 1.63	8.94 ± 2.33

Note: Compared with the control group, <0.05, <0.01.