ROS-Mediated Mitochondrial Pathway is Required for<i> Manilkara Zapota</i> (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-<i>κ</i>B Activities of HeLa Human Cervical Cancer Cells

<div>Close-up view of morphological changes in HeLa cells after treatment with<i> Manilkara zapota </i>leaf methanol extract at 12, 24, and 48 <i>μ</i>g/mL of<i> Manilkara zapota </i>leaf methanol extract for 24, 48, and 72 h and observed under an inverted light microscope (Magnification 400×). The cells showed the typical characteristics of apoptosis such as cellular shrinkage (CS), apoptotic bodies (AB), nuclear fragmentation (NF), nuclear compaction (NC), and membrane blebbing (MB).</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 3: ROS-Mediated Mitochondrial Pathway is Required for<i> Manilkara Zapota</i> (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-<i>κ</i>B Activities of HeLa Human Cervical Cancer Cells 

Figure 3 | ROS-Mediated Mitochondrial Pathway is Required for Manilkara Zapota (L.) P. Royen Leaf Methanol Extract Inducing Apoptosis in the Modulation of Caspase Activation and EGFR/NF-κB Activities of HeLa Human Cervical Cancer Cells 