Effect and Mechanism of ShiZhiFang on Uric Acid Metabolism in Hyperuricemic Rats
SZF upregulated the protein and gene expression of rOAT1 and rOAT3 in hyperuricemic rats. Protein levels were determined by Western blotting, were quantified through densitometry, and are expressed as the optical density ratio to β-actin. mRNA levels were determined through real-time PCR. Data are expressed as the mean ± SD (n = 10,7,8,7). <0.05 versus the normal group; <0.05 versus the model group; >0.05 versus the benzbromarone group.
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