Effect of Zishen Jiangtang Pill, a Chinese Herbal Product, on Rats with Diabetic Osteoporosis

Figure 4

Effect of ZJP on bone metabolism in diabetic rats. (a) STZ significantly increased the level of TRACP-5b in MOD group; ZJP completely inhibited the increase of TRACP-5b level in diabetic rats. (b) STZ significantly increased the level of CTX in MOD group; ZJP completely inhibited the increase of CTX levels in diabetic rats. (c) STZ significantly decreased the level of BALP in MOD group; ZJP attenuates the reduction of BALP level at the concentration of 3.0 g/kg/d in diabetic rats. (d) The level of PINP was not changed by STZ and ZJP administration. (e) STZ significantly decreased the level of BGP in MOD group; ZJP attenuates the reduction of BGP level in diabetic rats. (f) STZ significantly decreased the T-BMD, S-BMD, and LT-BMD; ZJP partially inhibited the reduction of T-BMD, S-BMD, and LT-BMD in diabetic rats (, , and , control versus MOD). Triangle indicates statistical significance (, , and , MOD versus MOD + H-ZJP or MOD + L-ZJP).

(a)

(b)

(c)

(d)

(e)

(f)