Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2018 (2018), Article ID 7201914, 10 pages
https://doi.org/10.1155/2018/7201914
Research Article

Effect of Zishen Jiangtang Pill, a Chinese Herbal Product, on Rats with Diabetic Osteoporosis

Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518033, China

Correspondence should be addressed to Huilin Li; moc.361@lhlmctzs

Received 31 August 2017; Revised 13 November 2017; Accepted 24 December 2017; Published 12 February 2018

Academic Editor: Vicky P. Chen

Copyright © 2018 Huilin Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Xia, Y. Zhong, G. Huang, Y. Chen, H. Shi, and Z. Zhang, “The relationship between insulin resistance and osteoporosis in elderly male type 2 diabetes mellitus and diabetic nephropathy,” Annales d'Endocrinologie, vol. 73, no. 6, pp. 546–551, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. D. C. Matthews, “The relationship between diabetes and periodontal disease,” Journal of the Canadian Dental Association, vol. 68, no. 3, pp. 161–164, 2002. View at Google Scholar · View at Scopus
  3. M. Prasannarong, K. Vichaiwong, and V. Saengsirisuwan, “Calorie restriction prevents the development of insulin resistance and impaired insulin signaling in skeletal muscle of ovariectomized rats,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1822, no. 6, pp. 1051–1061, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Unal, S. Aksak, Z. Halici et al., “Effects of diabetes mellitus on the rat liver during the postmenopausal period,” Journal of Molecular Histology, vol. 42, no. 3, pp. 273–287, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. B. Li, Y. Wang, Y. Liu, J. Ma, and Y. Li, “Altered gene expression involved in insulin signaling pathway in type II diabetic osteoporosis rats model,” Endocrine Journal, vol. 43, no. 1, pp. 136–146, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. V. Carnevale, E. Romagnoli, and E. D'Erasmo, “Skeletal involvement in patients with diabetes mellitus,” Diabetes/Metabolism Research and Reviews, vol. 20, no. 3, pp. 196–204, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Blakytny, M. Spraul, and E. B. Jude, “The diabetic bone: a cellular and molecular perspective,” The International Journal of Lower Extremity Wounds, vol. 10, no. 1, pp. 16–32, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. T. D. Rachner, S. Khosla, and L. C. Hofbauer, “Osteoporosis: now and the future,” The Lancet, vol. 377, no. 9773, pp. 1276–1287, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Mazziotti, J. Bilezikian, E. Canalis, D. Cocchi, and A. Giustina, “New understanding and treatments for osteoporosis,” Endocrine Journal, vol. 41, no. 1, pp. 58–69, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. S. A. G. Kemink, A. R. M. M. Hermus, L. M. J. W. Swinkels, J. A. Lutterman, and A. G. H. Smals, “Osteopenia in insulin-dependent diabetes mellitus: prevalence and aspects of pathophysiology,” Journal of Endocrinological Investigation, vol. 23, no. 5, pp. 295–303, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. P.-J. López-Ibarra, M. M. C. Pastor, F. Escobar-Jiménez et al., “Bone mineral density at time of clinical diagnosis of adult-onset type 1 diabetes mellitus,” Endocrine Practice, vol. 7, no. 5, pp. 346–351, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Wang, L. Cai, Y. Wang et al., “The protective effects of silibinin in the treatment of streptozotocin-induced diabetic osteoporosis in rats,” Biomedicine & Pharmacotherapy, vol. 89, pp. 681–688, 2017. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Vestergaard, L. Rejnmark, and L. Mosekilde, “Are antiresorptive drugs effective against fractures in patients with diabetes?” Calcified Tissue International, vol. 88, no. 3, pp. 209–214, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Seeman, B. Vellas, and C. Benhamou, “Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and older,” Journal of Bone Mineral Research, vol. 21, no. 7, pp. 1113–1120, 2010. View at Google Scholar
  15. J. J. Stepan, “Strontium ranelate: In search for the mechanism of action,” Journal of Bone and Mineral Metabolism, vol. 31, no. 6, pp. 606–612, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. A. V. Schwartz, “Efficacy of Osteoporosis Therapies in Diabetic Patients,” Calcified Tissue International, vol. 100, no. 2, pp. 165–173, 2017. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Ferron, J. Wei, T. Yoshizawa et al., “Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism,” Cell, vol. 142, no. 2, pp. 296–308, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. B. Guo, Z. C. Liu, B. Zeng et al., “Effect of Zishen Jiangtang Pills on Adipogenic Differentiation of Mice MSC and Its Mechanisms,” China Pharmacy, vol. 22, no. 11, pp. 985–987, 2011 (Chinese). View at Google Scholar
  19. B.-H. Mevik and R. Wehrens, “The pls package: principal component and partial least squares regression in R,” Journal of Statistical Software, vol. 18, no. 2, pp. 1–23, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Wickham, Ggplot2: Elegant Graphics for Data Analysis, Springer, New york, NY, USA, 2016.
  21. J. M. Halleen, S. L. Tiitinen, H. Ylipahkala, K. M. Fagerlund, and H. K. Väänänen, “Tartrate-resistant acid phosphates 5b (TRACP 5b) as a marker of bone resorption,” Clinical Laboratory, vol. 52, no. 9-10, pp. 499–509, 2006. View at Google Scholar · View at Scopus
  22. G. Wheater, M. Elshahaly, S. P. Tuck, H. K. Datta, and J. M. van Laar, “The clinical utility of bone marker measurements in osteoporosis,” Journal of Translational Medicine, vol. 11, no. 1, article 201, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. L. V. Hale, R. J. S. Galvin, J. Risteli et al., “PINP: a serum biomarker of bone formation in the rat,” Bone, vol. 40, no. 4, pp. 1103–1109, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. N. Morabito, A. Crisafulli, C. Vergara et al., “Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: A randomized double-blind placebo-controlled study,” Journal of Bone and Mineral Research, vol. 17, no. 10, pp. 1904–1912, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Oei, M. C. Zillikens, A. Dehghan et al., “High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: The Rotterdam study,” Diabetes Care, vol. 36, no. 6, pp. 1619–1628, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. S. C. Manolagas and R. L. Jilka, “Bone marrow, cytokines, and bone remodeling: emerging insights into the pathophysiology of osteoporosis,” The New England Journal of Medicine, vol. 332, no. 5, pp. 305–311, 1995. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Hamann, C. Goettsch, J. Mettelsiefen et al., “Delayed bone regeneration and low bone mass in a rat model of insulin-resistant type 2 diabetes mellitus is due to impaired osteoblast function,” American Journal of Physiology-Endocrinology and Metabolism, vol. 301, no. 6, pp. E1220–E1228, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Zhang, M. Liu, H. Li et al., “Traditional Chinese medicine Bushen-Jianpi-Huoxue decoction prevents diabetic osteoporosis in rats via Wnt and nuclear factor-kappa B signaling pathways,” International Journal of Rheumatic Diseases, vol. 20, no. 8, pp. 941–948, 2017. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Yamagishi, K. Nakamura, and H. Inoue, “Possible participation of advanced glycation end products in the pathogenesis of osteoporosis in diabetic patients,” Medical Hypotheses, vol. 65, no. 6, pp. 1013–1015, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. D. Ju, M. Liu, H. Zhao, and J. Wang, “Mechanisms of ‘kidney governing bones’ theory in traditional Chinese medicine,” Frontiers of Medicine in China, vol. 8, no. 3, pp. 389–393, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. Li, S.-S. Lü, G.-Y. Tang et al., “Effect of Morinda officinalis capsule on osteoporosis in ovariectomized rats,” Chinese Journal of Natural Medicines, vol. 12, no. 3, pp. 204–212, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. Y.-L. He, Y. Wang, J. M. Bullock et al., “Pharmacodynamics of vildagliptin in patients with type 2 diabetes during OGTT,” Clinical Pharmacology and Therapeutics, vol. 47, no. 5, pp. 633–641, 2007. View at Publisher · View at Google Scholar · View at Scopus
  33. L. I. Qiong, G. Qin, and F. Wang, “The clinical efficacy of systematic reinforcement treatment in patients with type 2 diabetes mellitus in community,” Journal of Handan Medical College, 2005. View at Google Scholar
  34. Y. Lin, Z. Lin, and Y. Huang, Compared research on glimepiride and gliclazide for treating diabetes mellitus type 2, Modern Hospital, 2011.
  35. F. F. Sheng, X. P. Dai, J. Qu et al., “NAMPT -3186C/T polymorphism affects repaglinide response nin chinese patients with Type 2 diabetes mellitus,” Clinical & Experimental Pharmacology & Physiology, vol. 38, no. 8, pp. 550–554, 2011. View at Google Scholar