Guzhi Zengsheng Zhitongwan, a Traditional Chinese Medicinal Formulation, Stimulates Chondrocyte Proliferation through Control of Multiple Genes Involved in Chondrocyte Proliferation and Differentiation
Table 5
Gene expression levels of pancartilaginous early chondrocyte markers.
Gene name
Blank (FPKM)
GZZSZTW (FPKM)
log2 fold change (GZZSZTW /Blank)
p value
Transcription factor SOX-9 (Sox9)
22.35
28.25
0.34
1.39E-06
Transcription factor SOX-5 (Sox5)
2.53
5.17
1.03
7.95E-14
Transcription factor SOX-6 (Sox6)
11.16
13.09
0.23
1.24E-10
Aggrecan core protein (Acan)
439.94
554.62
0.33
7.55E-177
Collagen alpha-1(II) chain (Col2a1)
16294.32
16870.22
0.05
3.43E-96
Collagen alpha-1(IX) chain(Col9a1)
1024.49
1188.74
0.21
4.10E-92
Collagen alpha-1(XI) chain (Col11a1)
838.24
1020.09
0.28
1.47E-232
Hyaluronan and proteoglycan link protein 1 (Hapln1)
