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Evidence-Based Complementary and Alternative Medicine
Volume 2018, Article ID 7420265, 8 pages
https://doi.org/10.1155/2018/7420265
Research Article

Nobiletin Inhibits Hepatic Lipogenesis via Activation of AMP-Activated Protein Kinase

1Division of Food and Animal Sciences, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea
2School of Food Biotechnology and Nutrition, Kyungsung University, Busan 48434, Republic of Korea

Correspondence should be addressed to Junsoo Lee; rk.ca.kubgnuhc@oosnuj

Received 29 September 2017; Revised 22 December 2017; Accepted 11 January 2018; Published 7 February 2018

Academic Editor: Luciana Dini

Copyright © 2018 Taewon Yuk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J.-M. Schwarz, P. Linfoot, D. Dare, and K. Aghajanian, “Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate isoenergetic diets,” American Journal of Clinical Nutrition, vol. 77, no. 1, pp. 43–50, 2003. View at Google Scholar · View at Scopus
  2. G. Marchesini, M. Brizi, G. Blanchi et al., “Nonalcoholic fatty liver disease: a feature of the metabolic syndrome,” Diabetes, vol. 50, no. 8, pp. 1844–1850, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Nguyen, V. Leray, M. Diez et al., “Liver lipid metabolism,” Journal of Animal Physiology and Animal Nutrition, vol. 92, no. 3, pp. 272–283, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. L. A. Adams, A. Feldstein, K. D. Lindor, and P. Angulo, “Nonalcoholic fatty liver disease among patients with hypothalamic and pituitary dysfunction,” Hepatology, vol. 39, no. 4, pp. 909–914, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Azzout-Marniche, D. Becard, C. Guichard, M. Foretz, P. Ferre, and F. Foufelle, “Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes,” Biochemical Journal, vol. 350, no. 2, pp. 389–393, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. G. F. Lewis, A. Carpentier, K. Adeli, and A. Giacca, “Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes,” Endocrine Reviews, vol. 23, no. 2, pp. 201–229, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Carling, “AMP-activated protein kinase: Balancing the scales,” Biochimie, vol. 87, no. 1, pp. 87–91, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. B. B. Kahn, T. Alquier, D. Carling, and D. G. Hardie, “AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism,” Cell Metabolism, vol. 1, no. 1, pp. 15–25, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. H.-Y. Quan, H.-D. Yuan, M. I. S. Jung, S. K. Ko, Y. G. Park, and S. H. Chung, “Ginsenoside Re lowers blood glucose and lipid levels via activation of AMP-activated protein kinase in HepG2 cells and high-fat diet fed mice,” International Journal of Molecular Medicine, vol. 29, no. 1, pp. 73–80, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. J. L. Goldstein, R. B. Rawson, and M. S. Brown, “Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis,” Archives of Biochemistry and Biophysics, vol. 397, no. 2, pp. 139–148, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. J. D. Horton, “Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis,” Biochemical Society Transactions, vol. 30, no. 6, pp. 1091–1095, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. J. L. Goldstein and M. S. Brown, “From fatty streak to fatty liver: 33 Years of joint publications in the JCI,” The Journal of Clinical Investigation, vol. 118, no. 4, pp. 1220–1222, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Eberlé, B. Hegarty, P. Bossard, P. Ferré, and F. Foufelle, “SREBP transcription factors: Master regulators of lipid homeostasis,” Biochimie, vol. 86, no. 11, pp. 839–848, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. W. Kim, Y. M. Kim, Y. M. Yang et al., “Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPK-activating lignan in Saururus chinensis,” Free Radical Biology & Medicine, vol. 48, no. 4, pp. 567–578, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. S.-L. Hwang, Y.-T. Jeong, X. Li et al., “Inhibitory cross-talk between the AMPK and ERK pathways mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle,” British Journal of Pharmacology, vol. 169, no. 1, pp. 69–81, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Nogata, K. Sakamoto, H. Shiratsuchi, T. Ishii, M. Yano, and H. Ohta, “Flavonoid composition of fruit tissues of citrus species,” Bioscience, Biotechnology, and Biochemistry, vol. 70, no. 1, pp. 178–192, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. J. A. Manthey, T. B. Cesar, E. Jackson, and S. Mertens-Talcott, “Pharmacokinetic study of nobiletin and tangeretin in rat serum by high-performance liquid chromatography-electrospray ionization-mass spectrometry,” Journal of Agricultural and Food Chemistry, vol. 59, no. 1, pp. 145–151, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. Y.-Q. Wu, C.-H. Zhou, J. Tao, and S.-N. Li, “Antagonistic effects of nobiletin, a polymethoxyflavonoid, on eosinophilic airway inflammation of asthmatic rats and relevant mechanisms,” Life Sciences, vol. 78, no. 23, pp. 2689–2696, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Miyata, T. Sato, M. Yano, and A. Ito, “Activation of protein kinase C βII/E-c-Jun NH2-terminal kinase pathway and inhibition of mitogen-activated protein/extracellular signal-regulated kinase 1/2 phosphorylation in antitumor invasive activity induced by the polymethoxy flavonoid, nobiletin,” Molecular Cancer Therapeutics, vol. 3, no. 7, pp. 839–847, 2004. View at Google Scholar · View at Scopus
  20. Y.-S. Lee, B.-Y. Cha, K. Saito et al., “Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice,” Biochemical Pharmacology, vol. 79, no. 11, pp. 1674–1683, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Choi, Y. Kim, H. Ham, Y. Park, H.-S. Jeong, and J. Lee, “Nobiletin suppresses adipogenesis by regulating the expression of adipogenic transcription factors and the activation of AMP-activated protein kinase (AMPK),” Journal of Agricultural and Food Chemistry, vol. 59, no. 24, pp. 12843–12849, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. W. Shen, Y. Xu, and Y.-H. Lu, “Inhibitory effects of Citrus flavonoids on starch digestion and antihyperglycemic effects in HepG2 cells,” Journal of Agricultural and Food Chemistry, vol. 60, no. 38, pp. 9609–9619, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Miyamoto, Y. Yasui, T. Tanaka, H. Ohigashi, and A. Murakami, “Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice,” Carcinogenesis, vol. 29, no. 5, pp. 1057–1063, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Zang, A. Zuccollo, X. Hou et al., “AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells,” The Journal of Biological Chemistry, vol. 279, no. 46, pp. 47898–47905, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. L. S. Wise and H. Green, “Participation of one isozyme of cytosolic glycerophosphate dehydrogenase in the adipose conversion of 3T3 cells,” The Journal of Biological Chemistry, vol. 254, no. 2, pp. 273–275, 1979. View at Google Scholar · View at Scopus
  26. H.-J. Kim, M. Miyazaki, W. C. Man, and J. M. Ntambi, “Sterol regulatory element-binding proteins (SREBPs) as regulators of lipid metabolism: polyunsaturated fatty acids oppose cholesterol-mediated induction of SREBP-1 maturation,” Annals of the New York Academy of Sciences, vol. 967, no. 1, pp. 34–42, 2002. View at Google Scholar · View at Scopus
  27. H. Shimano, N. Yahagi, M. Amemiya-Kudo et al., “Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes,” The Journal of Biological Chemistry, vol. 274, no. 50, pp. 35832–35839, 1999. View at Publisher · View at Google Scholar · View at Scopus
  28. B. K. Straub, P. Stoeffel, H. Heid, R. Zimbelmann, and P. Schirmacher, “Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis,” Hepatology, vol. 47, no. 6, pp. 1936–1946, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Bell, H. Wang, H. Chen et al., “Consequences of lipid droplet coat protein downregulation in liver cells: abnormal lipid droplet metabolism and induction of insulin resistance,” Diabetes, vol. 57, no. 8, pp. 2037–2045, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Li, S. Xu, M. M. Mihaylova et al., “AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice,” Cell Metabolism, vol. 13, no. 4, pp. 376–388, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Zhou, M. X. Shi, T. D. Mitchell et al., “Changes in rat adipocyte and liver glucose metabolism following repeated restraint stress,” Experimental Biology and Medicine, vol. 226, no. 4, pp. 312–319, 2001. View at Google Scholar
  32. M. Daval, F. Foufelle, and P. Ferré, “Functions of AMP-activated protein kinase in adipose tissue,” The Journal of Physiology, vol. 574, no. 1, pp. 55–62, 2006. View at Publisher · View at Google Scholar · View at Scopus
  33. J. Xiong, H. Yang, L. Wu et al., “Fluoxetine suppresses AMP-activated protein kinase signaling pathway to promote hepatic lipid accumulation in primary mouse hepatocytes,” The International Journal of Biochemistry & Cell Biology, vol. 54, pp. 236–244, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. H. Liu, H. Zhong, Y. Yin, and Z. Jiang, “Genistein has beneficial effects on hepatic steatosis in high fat-high sucrose diet-treated rats,” Biomedicine & Pharmacotherapy, vol. 91, pp. 964–969, 2017. View at Publisher · View at Google Scholar · View at Scopus
  35. Y.-R. Yun, J.-H. Kim, J. H. Kim, and M. H. Jung, “Protective effects of gomisin N against hepatic steatosis through AMPK activation,” Biochemical and Biophysical Research Communications, vol. 482, no. 4, pp. 1095–1101, 2017. View at Publisher · View at Google Scholar · View at Scopus