Adjuvant Therapy of Oral Chinese Herbal Medicine for Menopausal Depression: A Systematic Review and Meta-Analysis

Table 1

Basic characteristics of the included studies.

Reference	Sample size(I/C)	Age(I/C)	Duration of disease(I/C)	Diagnosis standard	Intervention group	Control group	Treatment duration	Outcome
Chen H, 2012	68/51	42-59 (50.20 ± 3.94); /43-58 (50.78 ± 4.08)	1.76 ± 0.99 y; /1.91 ± 1.25 y	Age; CCMD-3; HAMD	OCHM + antidepressant	antidepressant	8w	①②④
Chu YH, 2005	30/30	41-60 (47.86 ± 4.42) /41-60 (48.3 ± 4.06)	NS	Age; CCMD-3; HAMD	OCHM + HT	HT	6w	①②
Guo LH, 2016	43/43	40-55/42-55	(1.8 ± 0.6) y/(1.6 ± 0.8) y	Age; CCMD-3; HAMD	OCHM + antidepressant	antidepressant	6w	②
Jiang LX, 2016	98/98	41-60 (51.18 ± 4.52)/46-54(48.85 ± 3.27)	(4.8 ± 1.7) y/(4.2 ± 1.0) y	Age; CCMD-3; HAMD	OCHM + antidepressant	antidepressant	8w	①②③④
Li QY, 2009	34/34	41-56 (46.8 ± 4.1)	NS	Age; ICD-10; HAMD	OCHM + pharmacotherapy	pharmacotherapy	4w	①②④
Liu F, 2014	50/50	44-56 (49.3 ± 2.4); /43-57 (48.4 ± 2.3)	(2.3 ± 0.5) y/(2.1 ± 0.4)y	Age; ICD-10	OCHM + antidepressant	antidepressant	8w	①②
Liu R, 2007	30/30	(54.32 ± 3.29); /(54.0 ± 4.62)	(11.32 ± 6.25) m/(12.12 ± 4.58)m	Age; CCMD-3; HAMD	OCHM + antidepressant	antidepressant	8w	①②④
Ni JP, 2014	37/33	(52 ± 4)/(52 ± 4)	(9 ± 5) m/; (9 ± 5) m	Age; CCMD-3; HAMD	OCHM + antidepressant	antidepressant	4w	②④
Qu LX, 2010	30/30	45-55(51.6 ± 3.2); /45-55(50.8 ± 2.8)	(10.5±2.7)m; /(11.1±5.2)m	Age; CCMD-3; HAMD	OCHM + HT + antidepressant	HT + antidepressant	8w	①②④
Shi LR, 2016	45/45	41-58(46.4 ± 4.2); /42-57(44.8 ± 3.3)	(11.7 ± 4.5)m; /(10.6 ± 6.3)m	Age; CCMD-3; HAMD	OCHM + HT + antidepressant	HT + antidepressant	12w	①②
Sun GC, 2015	40/40	42.2 ± 2.60; /42.2 ± 2.60	(1.92 ± 1.06) y /NS	Age; ICD-10; HAMD	OCHM + antidepressant	antidepressant	4w	①
Sun YH, 2013	38/38	43-48(44.76 ± 2.24); /42-49(45.02 ± 3.15)	(2.38 ± 1.24) y; /(2.54 ± 1.56)y	Age; CCMD-3; HAMD	OCHM + HT + antidepressant	HT + antidepressant	4w	②
Wang CG, 2015	46/46	44-53(46.93 ± 6.8); /44-53(47.52 ± 7.2)	NS	Age; CCMD-3	OCHM + antidepressant	antidepressant	6w	①④
Wang SF, 2015	40/40	43-50(46.45 ± 6.15); /42-49(45.82 ± 5.45)	(2.75 ± 0.35)y; /(2.85 ± 0.43)y	Age; CCMD-3; HAMD	OCHM + HT + antidepressant	HT + antidepressant	3w	①
Wang XL, 2011	60/60	45-55(51.21 ± 3.17); /45-55(50.86 ± 3.41)	NS	Age; CCMD-3; HAMD	OCHM + HT + antidepressant	HT + antidepressant	8w	①
Wang Y, 2015	30/30	45.20 ± 2.90; /44.80 ± 3.10	NS	Age; ICD-10; HAMD	OCHM + antidepressant	antidepressant	8w	①②③④
Zhang CH, 2013	40/40	43-56(46.80 ± 4.10); /44-55(45.40 ± 3.2)	(11.50±4.30)m; /(10.90±6.50)m	Age; CCMD-3; HAMD	OCHM + HT + antidepressant	HT + antidepressant	3w	①②
Zhang CH, 2011	30/30	45-55(43.50 ± 12.43); /45-55(42.25 ±11.38)	NS	Age; CCMD-3; HAMD	OCHM + antidepressant	antidepressant	6w	①②
Zhang GQ, 2009	38/34	45-56(51.63 ± 3.68); /45-56(51.95 ± 3.86)	(9.44 ± 4.69)m; /(8.88 ± 4.65) m	Age; CCMD-3; HAMD	OCHM + antidepressant	antidepressant	4w	①②④
Zhang HZ, 2014	20/20	45-53; /46-52	(6-24)m; /(5-22)m	Age; CCMD-3	OCHM + HT	HT	12w	①②③
Zhang SJ, 2012	27/27	43-54(46.5 ± 6.3); /44-55(45.3 ± 7.2)	(3.2 ± 2.8)m; /(4.1 ± 3.2)m	Age; DSM-IV	OCHM + antidepressant	antidepressant	4w	②
Zhang XH, 2014	27/27	(47 ± 6.8); /(46.0 ± 6.8)	NS	Age; CCMD-3; HAMD	OCHM + antidepressant	antidepressant	8w	①②

CCMD-3: Criteria for Classification and Diagnosis of Mental Diseases; DSM-IV: Diagnostic and Statistical Manual; ICD-10: International Classification of Disease; m = month; y = year; NS: not stated.OCHM: oral Chinese herbal medicine; HT: hormone therapy; w = week; ①: Hamilton Rating Scale for Depression (HAMD) score; ②: response rate; ③: Kupperman Menopausal Index (KMI) score; ④: adverse events (AEs).