Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2018, Article ID 7878053, 14 pages
https://doi.org/10.1155/2018/7878053
Research Article

Electroacupuncture at ST36 Increases Bone Marrow-Derived Interstitial Cells of Cajal via the SDF-1/CXCR4 and mSCF/Kit-ETV1 Pathways in the Stomach of Diabetic Mice

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Correspondence should be addressed to Shi Liu; moc.oohay@oaguilihs

Received 6 September 2017; Revised 29 November 2017; Accepted 25 December 2017; Published 23 January 2018

Academic Editor: Ching-Liang Hsieh

Copyright © 2018 Jiao Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C.-P. Wang, C.-H. Kao, W.-K. Chen, W.-Y. Lo, and C.-L. Hsieh, “A single-blinded, randomized pilot study evaluating effects of electroacupuncture in diabetic patients with symptoms suggestive of gastroparesis,” The Journal of Alternative and Complementary Medicine, vol. 14, no. 7, pp. 833–839, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Yin, J. Chen, and J. D. Z. Chen, “Ameliorating effects and mechanisms of electroacupuncture on gastric dysrhythmia, delayed emptying, and impaired accommodation in diabetic rats,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 298, no. 4, pp. G563–G570, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. J. D. Huizinga, N. Zarate, and G. Farrugia, “Physiology, injury, and recovery of interstitial cells of Cajal: basic and clinical science,” Gastroenterology, vol. 137, no. 5, pp. 1548–1556, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. Chen, J. J. Xu, S. Liu, and X. H. Hou, “Electroacupuncture at ST36 ameliorates gastric emptying and rescues networks of interstitial cells of Cajal in the stomach of diabetic rats,” PLoS ONE, vol. 8, no. 12, article e83904, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. M.-F. Peng, K. Li, C. Wang et al., “Therapeutic effect and mechanism of electroacupuncture at Zusanli on plasticity of interstitial cells of Cajal: A study of rat ileum,” BMC Complementary and Alternative Medicine, vol. 14, article no. 186, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Alvarez-Dolado, R. Pardal, J. M. Garcia-Verdugo et al., “Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes,” Nature, vol. 425, no. 6961, pp. 968–973, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. Su, D. Liu, F. Wang et al., “Bone marrow derivation of interstitial cells of cajal in small intestine following intestinal injury,” Journal of Biomedicine and Biotechnology, vol. 2010, Article ID 164986, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Li, H. Kojima, K. Fujino et al., “Homing of the Bone Marrow-Derived Interstitial Cells of Cajal is Decreased in Diabetic Mouse Intestine,” Journal of Gastroenterology and Hepatology, vol. 26, no. 6, pp. 1072–1078, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Ding, Q. Yan, J.-W. Ruan et al., “Electro-acupuncture promotes survival, differentiation of the bone marrow mesenchymal stem cells as well as functional recovery in the spinal cord-transected rats,” BMC Neuroscience, vol. 10, article 35, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Baggiolini, “Chemokines and leukocyte traffic,” Nature, vol. 392, no. 6676, pp. 565–568, 1998. View at Publisher · View at Google Scholar · View at Scopus
  11. R. F. Wynn, C. A. Hart, C. Corradi-Perini et al., “A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow,” Blood, vol. 104, no. 9, pp. 2643–2645, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. J. D. Huizinga, L. Thuneberg, M. Klüppel, J. Malysz, H. B. Mikkelsen, and A. Bernstein, “W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity,” Nature, vol. 373, no. 6512, pp. 347–349, 1995. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Isozaki, S. Hirota, A. Nakama et al., “Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in Ws Ws mutant rats,” Gastroenterology, vol. 109, no. 2, pp. 456–464, 1995. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Chi, Y. Chen, L. Zhang et al., “ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours,” Nature, vol. 467, no. 7317, pp. 849–853, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. L. Tian, B. Zhu, and S. Liu, “Electroacupuncture at ST36 protects ICC networks via mSCF/Kit-ETV1 signaling in the stomach of diabetic mice,” Evidence-Based Complementary and Alternative Medicine, vol. 2017, Article ID 3980870, 2017. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Okabe, M. Ikawa, K. Kominami, T. Nakanishi, and Y. Nishimune, “‘Green mice’ as a source of ubiquitous green cells,” FEBS Letters, vol. 407, no. 3, pp. 313–319, 1997. View at Publisher · View at Google Scholar · View at Scopus
  17. S.-Y. Wang, D. Zhang, L.-M. Tang, S.-Y. Li, M. Wen, and X.-J. Song, “Effects of electroacupuncture stimulation at ‘Zusanli’ acupoint on hepatic no release and blood perfusion in mice,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 826805, 6 pages, 2015. View at Publisher · View at Google Scholar
  18. Y. Chen, J. Xu, S. Liu, and X. Hou, “Electroacupuncture at ST36 increases contraction of the gastric antrum and improves the SCF/c-kit pathway in diabetic rats,” American Journal of Chinese Medicine, vol. 41, no. 6, pp. 1233–1249, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. V. Di Marzo, R. Capasso, I. Matias et al., “The role of endocannabinoids in the regulation of gastric emptying: Alterations in mice fed a high-fat diet,” British Journal of Pharmacology, vol. 153, no. 6, pp. 1272–1280, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Hess, L. Li, M. Martin et al., “Bone marrow-derived stem cells initiate pancreatic regeneration,” Nature Biotechnology, vol. 21, no. 7, pp. 763–770, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Ishii, S. Tsuji, M. Tsujii et al., “Restoration of gut motility in Kit-deficient mice by bone marrow transplantation,” Journal of Gastroenterology, vol. 44, no. 8, pp. 834–841, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Wu, J. Peng, M. Wu et al., “Experimental study of low-frequency electroacupuncture-induced differentiation of bone marrow mesenchymal stem cells into chondrocytes,” International Journal of Molecular Medicine, vol. 27, no. 1, pp. 79–86, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Peled, I. Petit, O. Kollet et al., “Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4,” Science, vol. 283, no. 5403, pp. 845–848, 1999. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Kaku, M. Kitami, J. M. Rosales Rocabado, T. Ida, Y. Akiba, and K. Uoshima, “Recruitment of bone marrow-derived cells to the periodontal ligament via the stromal cell-derived factor-1/C-X-C chemokine receptor type 4 axis,” Journal of Periodontal Research, vol. 52, no. 4, pp. 686–694, 2017. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Hamdan, Z. Zhou, and E. S. Kleinerman, “Blocking SDF-1a/CXCR4 downregulates PDGF-B and Inhibits bone marrow-derived pericyte differentiation and tumor vascular expansion in ewing tumors,” Molecular Cancer Therapeutics, vol. 13, no. 2, pp. 483–491, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. L. Lin, L.-M. Xu, W. Zhang et al., “Roles of stem cell factor on the depletion of interstitial cells of Cajal in the colon of diabetic mice,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 298, no. 2, pp. G241–G247, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Lorincz, D. Redelman, V. J. Horváth, M. R. Bardsley, H. Chen, and T. Ördög, “Progenitors of Interstitial Cells of Cajal in the Postnatal Murine Stomach,” Gastroenterology, vol. 134, no. 4, pp. 1083–1093, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Ran, I. Sirota, Z. Cao et al., “Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth,” Cancer Discovery, vol. 5, no. 3, pp. 304–315, 2015. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Hayashi, M. R. Bardsley, and Y. Toyomasu, “Platelet-derived growth factor receptor-α regulates proliferation of gastrointestinal stromal tumor cells with mutations in KIT by stabilizing ETV1,” Gastroenterology, 2015. View at Publisher · View at Google Scholar