Subgroups Objective response rate (ORR) Disease control rate (DCR) Studies Cases SM RR(95 CI) I 2 p Studies Cases SM RR(95 CI) I 2 P Total 34 2714 FEM 1.30 [1.19, 1.42] 0% P < 0.00001 33 2664 FEM 1.17 [1.12, 1.22] 3% P < 0.00001 Different drugs and doses (Figures S8 - 9 ) Aidi injection (100 ml) 3 262 FEM 1.39 [1.08, 1.80] 0% P = 0.01 3 262 FEM 1.27 [1.07, 1.50] 27% P = 0.005 Aidi injection (80-100 ml) 4 338 FEM 1.37 [1.13, 1.67] 0% P = 0.002 4 338 FEM 1.19 [1.06, 1.33] 0% P = 0.002 Aidi injection (80 ml) 2 188 FEM 1.40 [1.00, 1.95] 0% P = 0.05 2 188 FEM 1.25 [1.00, 1.55] 0% P = 0.05 Aidi injection (60 ml) 1 38 No 1.25 [0.40, 3.95] No P = 0.70 1 38 FEM 1.17 [0.48, 2.83] No P = 0.73 Aidi injection (50 ml) 22 1690 FEM 1.27 [1.14, 1.42] 4% P < 0.0001 21 1640 FEM 1.16 [1.10, 1.21] 0% P < 0.00001 Aidi injection (40 ml) 1 120 No 1.18 [0.83, 1.68] No P = 0.36 1 120 No 1.06 [0.92, 1.23] No P = 0.43 Aidi injection (Unclear) 1 78 No 1.17 [0.62, 2.19] No P = 0.63 1 78 FEM 1.20 [0.99, 1.46] No P = 0.07 Different chemotherapy regimens (Figures S10 - 11 ) Aidi injection plus DP 24 1767 FEM 1.27 [1.15, 1.41] 0% P < 0.00001 23 1717 FEM 1.17 [1.12, 1.24] 0% P < 0.00001 Aidi injection plus DC 4 380 FEM 1.36 [1.05, 1.76] 0% P = 0.02 4 380 FEM 1.16 [1.07, 1.26] 0% P = 0.0004 Aidi injection plus DO 2 142 FEM 1.37 [1.02, 1.85] 0% P = 0.04 2 142 FEM 1.07 [0.93, 1.24] 0% P = 0.35 Aidi injection plus DL 1 135 No 1.41 [0.99, 2.01] No P = 0.05 1 135 No 1.47 [1.10, 1.96] No P = 0.009 Aidi injection plus DN 1 100 No 1.63 [1.00, 2.64] No P = 0.05 1 100 No 1.33 [0.98, 1.82] No P = 0.07 Aidi injection plus docetaxel 2 190 FEM 1.19 [0.82, 1.73] 0% P = 0.37 2 190 FEM 1.06 [0.89, 1.26] 0% P = 0.52 Different evaluation criteria (Figures S12 - 13 ) WHO Criteria 27 2188 FEM 1.30 [1.18, 1.43] 0% P < 0.00001 27 2188 FEM 1.17 [1.12, 1.22] 0% P < 0.00001 RECIST 7 526 FEM 1.30 [1.07, 1.57] 0% P = 0.008 6 476 FEM 1.18 [1.06, 1.32] 41% P = 0.003
