Antipsoriatic Effects of Wannachawee Recipe on Imiquimod-Induced Psoriasis-Like Dermatitis in BALB/c Mice

Figure 3

Phenotypical presentation of the effect of WCR treatment on the dorsal skin of IMQ-induced psoriasis-like dermatitis. (A) Phenotypical presentation of dorsal skin of the five dermatitis groups; group II (IMQ, (a–d)), group III (acitretin 5.14 mg/kg + IMQ, (e–h)), group IV (WCR 800 mg/kg + IMQ, (i–l)), group V (WCR 1,600 mg/kg + IMQ, (m–p)), and group VI (WCR 3,200 mg/kg + IMQ, (q–t)) on day 1 (no treatment), day 7 (after IMQ treatment, psoriasis-like dermatitis-induced mice), day 12 (acitretin- or WCR-treated psoriasis-like dermatitis-induced mice), and day 16 (end of acitretin or WCR treatment). (B–F) PASI intensity scores (erythema, thickness, and scales) recorded on days 1–16 for mice groups II–VI. (G) PASI cumulative scores recorded for 10 days after administration of acitretin or WCR. significant at compared with all other groups. Grp, group; Aci, acitretin; WCR, Wannachawee Recipe; and IMQ, imiquimod.