Evidence-Based Complementary and Alternative Medicine / 2018 / Article / Fig 2

Review Article

Ozone Therapy as Adjuvant for Cancer Treatment: Is Further Research Warranted?

Figure 2

Delayed healing in cancer patients. Twenty-eight cancer patients treated with local O3T because of delayed healing after RT (3 patients) or after surgery (25 patients, 7 of whom previously received RT in the same anatomical area). Most patients needed further cancer treatment. The study group consisted of 18 females and 10 males, mean age 56±16 years (range: 21-95 years). Wound locations were 15 (54%) breast, 6 head and neck, and 7 in other areas. Mean duration of the wound: 48±43 days (range: 10-182 days), mean area of wound: 35.4±64.7 cm2 (range: 0.6-293 cm2), time-to-healing: 26±14 days (range: 4-50 days), ozone-sessions: 8±4 (range: 2-18). Local O3T was conducted at O3/O2 concentration between 50 μg/ml and 20 μg/ml, usually in two sessions per week. Reintervention for wound closure was programmed for 19 patients but was preempted in 16 of them (84%) due to O3T. Preliminary report was presented in 1999, in the X Congress of the Spanish Society of Radiation Oncology, and summarized the collaborative experience from the Hospital Quirónsalud (Barcelona) and the Dr. Negrín University Hospital (Las Palmas) [20]. Error bars show means ± SD.