Understanding the Multitarget Pharmacological Mechanism of the Traditional Mongolian Common Herb Pair GuangZao-RouDouKou Acting on Coronary Heart Disease Based on a Bioinformatics Approach

Figure 7

The FCN alters the expression of genes that are related to stress reaction, apoptosis and necrosis of cardiomyocytes, the inflammatory response. (a–f) mRNA levels of the proinflammatory cytokines TNF-α, IL-1β, stress cytokine p38, and the proapoptosis cytokines P53, Bax, and antiapoptosis cytokines Bcl-2, as well as Bcl-2/Bax ratio of the injured myocardium of each intervention group (n = 6 mice per group). Mean values ± SD. are represented. P < 0.01 versus the control group, P < 0.05 versus the control group, P < 0.01 versus model, and P < 0.05 versus model.

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