Understanding the Multitarget Pharmacological Mechanism of the Traditional Mongolian Common Herb Pair GuangZao-RouDouKou Acting on Coronary Heart Disease Based on a Bioinformatics Approach
The FCN alters the expression of genes that are related to stress reaction, apoptosis and necrosis of cardiomyocytes, the inflammatory response. (a–f) mRNA levels of the proinflammatory cytokines TNF-α, IL-1β, stress cytokine p38, and the proapoptosis cytokines P53, Bax, and antiapoptosis cytokines Bcl-2, as well as Bcl-2/Bax ratio of the injured myocardium of each intervention group (n = 6 mice per group). Mean values ± SD. are represented. P < 0.01 versus the control group, P < 0.05 versus the control group, P < 0.01 versus model, and P < 0.05 versus model.
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